Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Latest results on J/\psi anomalous suppression. International Symposium on Particles Strings and Cosmology 9 PASCOS 03, Jan 2003, Bombay, India. ⟨in2p3-00014144⟩
  • W. Adam, W. Beaumont, V. Zhukov, D. Contardo, N. Lumb, et al.. Test beam analysis of the effect of highly ionising particles on the silicon strip tracker. 2003, pp.41. ⟨in2p3-00020330⟩
  • P. Depasse, M. Goyot. Etude d'une matrice de photodiodes a avalanche associee a des cristaux scintillants (LSO et LuAP). 2003, pp.23. ⟨in2p3-00014122⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. A measurement of the branching fractions of the b-quarks into charged and neutral b-hadrons. Physics Letters B, 2003, 576, pp.29-42. ⟨10.1016/j.physletb.2003.09.070⟩. ⟨in2p3-00021584⟩
  • M.-G. Porquet, Ts. Venkova, A. Astier, A. Bauchet, I. Deloncle, et al.. Evolution of the \pi g_{9/2}\otimes \nu h_{11/2} configuration in the neutron-rich ^{110,112}_{45}Rh and ^{114,116}_{47}Ag isotopes. The European physical journal. A, Hadrons and Nuclei, 2003, 18, pp.25-30. ⟨10.1103/PhysRevLett.109.032502⟩. ⟨in2p3-00014063⟩
  • R. Arnaldi, G. Usai, K. Banicz, K. Borer, J. Buytaert, et al.. First results from the NA60 experiment at CERN. Rencontres de Moriond on QCD and High-Energy Hadronic Interactions 38, 2003, Les Arcs, France. pp.4. ⟨in2p3-00014136⟩
  • A. Bahaoui, C. Fayard, T. Mizutani, B. Saghai. Low energy \bar{K}N interactions and Faddeev calculation of the K^-d scattering length in isospin and particle bases. Physical Review C, 2003, 68, pp.064001. ⟨in2p3-00020103⟩
  • R. Kirsch, W. Tromeur, Y. Champelovier, M. Miguet. Pulsation du faisceau - Accelerateur 2,5 MV - VdG. 2003, pp.34. ⟨in2p3-00013956⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for a Higgs boson decaying to weak boson pairs at LEP. Physics Letters B, 2003, 568, pp.191-204. ⟨10.1016/j.physletb.2003.06.057⟩. ⟨in2p3-00013951⟩
  • G. Chanfray, M. Ericson, M. Oertel. In-medium modification of the isovector pion-nucleon amplitude. Physics Letters B, 2003, 563, pp.61-67. ⟨10.1016/S0370-2693(03)00596-3⟩. ⟨in2p3-00012354⟩

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