Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Gavarini. Etude de la pellicule d'alteration formee en surface des verres LaYSiAlO et CeYSiAlO par ERDA et RBS. Journees on Ion Beam Analysis - IBAF, Mar 2003, Nouan Le Fuzelier, France. ⟨in2p3-00020195⟩
  • N. Chevarier. Bilan des ressources en analyse par faisceaux d'ions en France. Journees on Ion Beam Analysis - IBAF, Mar 2003, Nouan Le Fuzelier, France. ⟨in2p3-00020194⟩
  • E. Gangler. The Nearby Supernova factory experiment. RTN Workshop on the physics of Supernovae, Mar 2003, Ringberg, Germany. ⟨in2p3-00020355⟩
  • J.-M. Richard, X. Artru. Constraints on spin observables in \overline{p}p \rightarrow \overline{\Lambda}\Lambda. International Conference on Low-Energy Antiproton Physics 8 LEAP 03, Mar 2003, Yokohama, Japan. pp.171-175. ⟨in2p3-00020010⟩
  • J-L. Boldo, C.P. Constantinidis, F. Gieres, M. Lefrançois, O. Piguet. Observables in topological theories: a superspace formulation. International Conference on Renormalization Group and Anomalies in Gravity ad Cosmology, Mar 2003, Ouro Preto, Brazil. pp.30-35, ⟨10.1016/S0920-5632(03)02397-1⟩. ⟨in2p3-00020050⟩
  • J.-C. Thomas, N.L. Achouri, J. Aysto, R. Béraud, Bertram Blank, et al.. Spectroscopic studies of neutron-deficient light nuclei: decay properties of ^{21}Mg, ^{25}Si and ^{26}P. International Conference PROCON 2003 2, Feb 2003, Legnaro, Italy. pp.235-244, ⟨10.1063/1.1615179⟩. ⟨in2p3-00014201⟩
  • A. Le Fevre, C. Schwarz, G. Auger, N. Bellaize, M.L. Begemann-Blaich, et al.. Source shape determination with directional correlation functions. International Winter Meeting on Nuclear Physics 41, Jan 2003, Bormio, Italy. pp.178-187. ⟨in2p3-00022308⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Recent results on J/\psi suppression from the NA50 experiment. International Winter Meeting of Nuclear Physics 41, Jan 2003, Bormio, Italy. pp.43-51. ⟨in2p3-00022313⟩
  • M. Pichon, R. Bougault, F. Gulminelli, O. Lopez, M-L. Begemann-Blaich, et al.. Bimodality in binary Au+Au collisions from 60 to 100MeV/u. International Winter Meeting on Nuclear Physics 41, Jan 2003, Bormio, Italy. pp.149-164. ⟨in2p3-00022316⟩
  • D. Dauvergne. Deceleration of highly charged heavy ions in channeling conditions. Conference Internationale ICACS, Jan 2003, Puri, India. ⟨in2p3-00013736⟩

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