Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V. Brigljevic, G. Bruno, E. Cano, A. Csilling, S. Cittolin, et al.. Using XDAQ in Application Scenarios of the CMS experiment. Conference for Computing in High-Energy and Nuclear Physics - CHEP03, Mar 2003, La Jolla, United States. pp.6. ⟨in2p3-00014141⟩
  • E. Chabanat, N. Estre. New vertex reconstruction algorithm in CMS. Conference for Computing in High-Energy and Nuclear Physics - CHEP03, Mar 2003, La Jolla, United States. ⟨in2p3-00024006⟩
  • G.-S. Muanza, P. Lebrun, D. Teyssier. Search for invisible Higgs boson decay in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. Rencontres de Moriond: QCD and Hadronic Interactions at High Energy 38, Mar 2003, Les Arcs, France. ⟨in2p3-00020299⟩
  • D. Teyssier, G.-S. Muanza. Search for the Standard Model Higgs boson in e^+e^- collisions at center-of-mass energies up to 209 GeV at LEP. Rencontres de Moriond: QCD and Hadronic Interactions at High Energy 38, Mar 2003, Les Arcs, France. ⟨in2p3-00020300⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Recent results on anomalous J/\psi suppression in Pb-Pb collisions at 158 AGeV/c. Rencontres de Moriond QCD and Hadronic Interactions 38, Mar 2003, Les Arcs, France. pp.233-236. ⟨in2p3-00014017⟩
  • V. Sanglard. The EDELWEISS experiment and dark matter direct detection. Rencontres de Moriond Electroweak Interactions and Unified Theories 38, Mar 2003, Les Arcs, France. pp.10. ⟨in2p3-00014264⟩
  • R. Rapp, L. Grandchamp. Theoretical overview on (hidden) charm in high-energy heavy-ion collisions. Conference on Strangeness in Quark Matter 7, Mar 2003, Atlantic Beach, United States. pp.10. ⟨in2p3-00020168⟩
  • D. Jouan, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. The production of \phi, \omega and \rho mesons in p-, d-, S-. and Pb-induced reactions at the CERN SPS. 7th International Conference on Strangeness in Quark Matter - SQM 2003, Mar 2003, Atlantic Beach, United States. pp.S277-S282, ⟨10.1088/0954-3899/30/1/033⟩. ⟨in2p3-00024631⟩
  • R. Arnaldi, K. Banicz, K. Borer, J. Buytaert, J. Castor, et al.. First results and future perspectives of the NA60 experiment. International Conference on Strangeness in Quark Matter 7 SQM2003, Mar 2003, Atlantic Beach, United States. pp.S507-S512. ⟨in2p3-00021586⟩
  • N. Chevarier. Bilan des ressources en analyse par faisceaux d'ions en France. Journees on Ion Beam Analysis - IBAF, Mar 2003, Nouan Le Fuzelier, France. ⟨in2p3-00020194⟩

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