Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Lethuillier. The CMS PbWO_4 electromagnetic calorimeter. Proceedings of the Advanced Studies Institute Physics at LHC INTAS Monitoring Conference, Jul 2003, Prague, Czech Republic. pp.A429-A436. ⟨in2p3-00020327⟩
  • J.-M. Mackowski, L. Pinard, A. Remillieux. Low loss coatings for the VIRGO large mirrors. Edoardo Amaldi Conference on Gravitational Waves, Jul 2003, Tirrenia,Pise, Italy. ⟨in2p3-00020120⟩
  • B. Nsouli, T. Darwish, J.-P. Thomas, K. Zahraman, M. Roumie. Ni Cu Zn and Pb background values determination in representative Lebanese soil using the thick target PIXE technique. International Conference on Ion Beam Analysis 16, Jun 2003, Albuquerque, United States. pp.181-186, ⟨10.1016/j.nimb.2004.01.050⟩. ⟨in2p3-00014248⟩
  • G. Chanfray. In medium modification of the isovector pion-nuclei amplitude. Workshop on Chiral Dynamics of Hadrons and Hadrons in a Medium, Jun 2003, Valence, Spain. ⟨in2p3-00020161⟩
  • C. Volant, K. Turzo, W. Trautmann, G. Auger, M.-L. Begemann-Blaich, et al.. Intranuclear cascade+percolation+evaporation model applied to the ^{12}C+^{197}Au system at 1 GeV/nucleon. International Conference on Nucleus-Nucleus Collisions (NN2003) 8, Jun 2003, Moscow, Russia. pp.545-548, ⟨10.1016/S0375-9474(04)90341-7⟩. ⟨in2p3-00021660⟩
  • H. Ohnishi, R. Arnaldi, K. Banicz, K. Borer, J. Buytaert, et al.. The NA60 experiment at CERN SPS - First results and prospects. Nucleus-Nucleus 2003, Jun 2003, Moscou, Russia. pp.49-52, ⟨10.1016/j.nuclphysa.2004.01.009⟩. ⟨in2p3-00014138⟩
  • D. Drain. Latest results of the EDELWEISS experiment. Rencontres de Blois 15, Jun 2003, Blois, France. ⟨in2p3-00020210⟩
  • P. Papka, C. Beck, F. Haas, V. Rauch, Marc Rousseau, et al.. Large deformation effects in the N=Z ^{44}Ti compound nucleus. International Conference on Nuclear Reaction Mechanisms 10, Jun 2003, Varenna, Italy. pp.373-380. ⟨in2p3-00020316⟩
  • J. Marteau. La physique des neutrinos massifs approche experimentale. ENCRE 2003, Jun 2003, Aussois, France. ⟨in2p3-00020440⟩
  • R. Barbier, Y. Déclais, C. Dujardin, Nicolas B. Garnier, I.A. Kamenskikh, et al.. Two heads small animal PET prototype with LSO/LuAP coupled to a multi-anode PMT. International Conference Imaging Technologies in Biomedical Sciences, May 2003, Athens, Greece. pp.175-179, ⟨10.1016/j.nima.2004.03.116⟩. ⟨in2p3-00020332⟩

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