Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Gieres. On the defining relations for supersymmetric quantum mechanics. International Conference on Progress in Supersymmetric Quantum Mechanics - PSQM'03, Jul 2003, Valladolid, Spain. ⟨in2p3-00024866⟩
  • N. Redon, A. Prévost, D. Guinet, P. Lautesse, M. Meyer, et al.. Deformation of the very neutron-deficient rare-earth nuclei produced with the SPIRAL ^{76}Kr radioactive beam and studied with EXOGAM + DIAMANT. International Conference on The Labyrinth in Nuclear Structure, an EPS Nuclear Physics Divisional Conference, Jul 2003, Aghia Pelaghia, Crète, Greece. pp.208-212, ⟨10.1063/1.1691709⟩. ⟨in2p3-00023632⟩
  • Maurice R. Kibler. Classifying chemical elements and particles: from the atomic to the sub-atomic world. Second Harry Wiener International Memorial Conference, Jul 2003, Banff, Canada. pp.297-329. ⟨hal-00000783v2⟩
  • M. R. Kibler. A Group-Theoretical Approach to the Periodic Table of Chemical Elements: Old and New Developments. 2nd Harry Wiener International Memorial Conference: "The Periodic Table: Into the 21st Century", Jul 2003, Brewster's KGR near Banff, Alberta, Canada. ⟨in2p3-00023845⟩
  • G. Duchêne, J. Robin, A. Odahara, T. Byrski, F.A. Beck, et al.. Decay-out of ^{151}Tb Yrast superdeformed band and shape coexistence. International Conference on The Labyrinth in Nuclear Structure, an EPS Nuclear Physics Divisional Conference, Jul 2003, Aghia Pelaghia, Crète, Greece. pp.222-229, ⟨10.1063/1.1691711⟩. ⟨in2p3-00023633⟩
  • B. Herskind, G.B. Hagemann, G. Sletten, Th. Dossing, C. Ronn Hansen, et al.. Hyperdeformed shapes and Jacobi Transitions in ^{126}Ba. International conference on the labyrinth in nuclear structure, an EPS Nuclear Physics divisional conference, Jul 2003, Crete, Greece. pp.303-315. ⟨in2p3-00022024⟩
  • N. Redon. Deformation of the very neutron-deficient rare-earth nuclei produced with the SPIRAL {76}Kr radioactive bean and studied with EXOGAM + DIAMANT. International Conference on the Labyrinth in Nuclear Structure, Jul 2003, Crete, Greece. ⟨in2p3-00020322⟩
  • J. Dobaczewski, J.P. Vivien, K. Zuber, P. Bednarczyk, T. Byrski, et al.. Study of superdeformation in A \sim 60 mass region; high rsolution \gamma-ray spectroscopy at Euroball IV with the Recoil filter detector and the Euclides charged particle detector. International Conference on the labyrinth in nuclear structure, an EPS nuclear physics divisional conference, Jul 2003, Crete, Greece. pp.273-279. ⟨in2p3-00022038⟩
  • J. Gascon. Dark matter direct searches. Conference on Low Temperature Detectors - LTD10, Jul 2003, Genes, Italy. pp.96-100, ⟨10.1016/j.nima.2003.11.251⟩. ⟨in2p3-00020209⟩
  • L. Chabert. Recherche de matiere noire par l'experience EDELWEISS. Congres de la Societe Francaise de Physique, Jul 2003, Lyon, France. ⟨in2p3-00020208⟩

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