Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • N. Bérerd, N. Moncoffre, A. Chevarier, Y. Pipon, H. Faust, et al.. Thermal- and radiation-enhanced diffusion of uranium in oxidised zirconium. 13th International Conference on Surface Modification of Materials by Ion Beams, Sep 2003, San Antonio, Texas, United States. pp.10-14, ⟨10.1016/j.surfcoat.2004.08.076⟩. ⟨in2p3-00024603⟩
  • B. Farizon, M. Farizon, M.J. Gaillard, F. Gobet, S. Ouaskit, et al.. Fragmentation d'agregats et transition de phase dans un systeme fini. Pole MACOMS Systemes Dynamiques et Systemes Complexes, Sep 2003, Casablanca, Morocco. ⟨in2p3-00020191⟩
  • J. Lukasik, W. Trautmann, G. Auger, M.L. Begemann-Blaich, N. Bellaize, et al.. INDRA@GSI: collective flow in Au+Au collisions. Heavy ion reaction from nuclear to quark matter, Sep 2003, Erice, Italy. pp.77-80, ⟨10.1016/j.ppnp.2004.02.013⟩. ⟨in2p3-00021861⟩
  • X. Artru, J.-M. Richard. General constraints on spin observables, applications to 
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    and to polarized quark distributions. International Workshop on High-Energy-Spin Physics, Sep 2003, Dubna, Russia. pp.S126-S132. ⟨in2p3-00020319⟩
  • X. Artru, J.-M. Richard. Positivity constraints on spin observables taking as examples the polarized quark densities and the reaction antiproton + proton \to \bar{\Lambda + \Lambda}. NATO-ARW Workshop Spin'03, Sep 2003, Dubna, Russia. ⟨in2p3-00020160⟩
  • O. Stézowski. ROOT as a framework for AGATA. AGATA week Meeting, Sep 2003, Legnaro,Padova, Italy. ⟨in2p3-00020323⟩
  • E. Chabanat, J. d'Hondt, N. Estre, R. Frühwirth, K. Prokofiev, et al.. Vertex reconstruction in CMS. 12th International Workshop on Vertex Detectors - Vertex 2003, Sep 2003, Low Wood, Lake Windermere, Cumbria, United Kingdom. pp.188-191, ⟨10.1016/j.nima.2005.04.050⟩. ⟨in2p3-00024689⟩
  • M. Keil, R. Arnaldi, K. Banicz, K. Borer, J. Buytaert, et al.. The NA60 silicon pixel telescope. 12th International Workshop on Vertex Detectors, Sep 2003, Low Wood, Lake Windermere, Cumbria, United Kingdom. pp.20-26, ⟨10.1016/j.nima.2005.04.019⟩. ⟨in2p3-00024254⟩
  • K. Ziemons, E. Auffray, R. Barbier, G. Brandenburg, P. Bruyndonckx, et al.. The ClearPET^{TM} project: development of a 2nd generation high-performance small animal PET scanner. 7th International Conference on Inorganic Scintillators and their Use in Scientific and Industrial Applications SCINT 2003, Sep 2003, Valencia, Spain. pp.307-311, ⟨10.1016/j.nima.2004.08.032⟩. ⟨in2p3-00024319⟩
  • C. Cohen, D. Dauvergne. High energy ion channeling - Principles and typical applications. Ecole d'Eté Franco-Allemande - TRACK03, Sep 2003, Mühlausen, Germany. pp.40-71, ⟨10.1016/j.nimb.2004.03.017⟩. ⟨in2p3-00020480⟩

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