Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Xabier Cid Vidal, Monica d'Onofrio, Patrick J Fox, Riccardo Torre, Keith A Ulmer, et al.. Report from Working Group 3 : Beyond the Standard Model Physics at the HL-LHC and HE-LHC. [Research Report] CERN-2019-007, CERN. 2019, pp.585-865. ⟨hal-01975140⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for long-lived particles using nonprompt jets and missing transverse momentum with proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 797, pp.134876. ⟨10.1016/j.physletb.2019.134876⟩. ⟨hal-02171525⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement and interpretation of differential cross sections for Higgs boson production at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 792, pp.369-396. ⟨10.1016/j.physletb.2019.03.059⟩. ⟨hal-01974855⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Studies of Beauty Suppression via Nonprompt D^0 Mesons in Pb-Pb Collisions at Q^2 = 4 \rm GeV^2. Physical Review Letters, 2019, 123 (2), pp.022001. ⟨10.1103/PhysRevLett.123.022001⟩. ⟨hal-01921703⟩
  • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Investigations of Anisotropic Flow Using Multiparticle Azimuthal Correlations in pp, p-Pb, Xe-Xe, and Pb-Pb Collisions at the LHC. Physical Review Letters, 2019, 123 (14), pp.142301. ⟨10.1103/PhysRevLett.123.142301⟩. ⟨hal-02073498⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the differential Drell-Yan cross section in proton-proton collisions at \sqrt{\mathrm{s}} = 13 TeV. Journal of High Energy Physics, 2019, 12, pp.059. ⟨10.1007/JHEP12(2019)059⟩. ⟨hal-01982959⟩
  • J. Dudouet, A. Lemasson, G. Maquart, F. Nowacki, D. Verney, et al.. Excitations of the magic N=50 neutron-core revealed in ^{81}Ga. Physical Review C, 2019, 100 (1), pp.011301. ⟨10.1103/PhysRevC.100.011301⟩. ⟨hal-02188091⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Centrality and pseudorapidity dependence of the transverse energy density in pPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Physical Review C, 2019, 100 (2), pp.024902. ⟨10.1103/PhysRevC.100.024902⟩. ⟨hal-01909251⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Centrality and pseudorapidity dependence of the charged-particle multiplicity density in Xe–Xe collisions at \sqrt{s_{\rm NN}} =5.44TeV. Physics Letters B, 2019, 790, pp.35-48. ⟨10.1016/j.physletb.2018.12.048⟩. ⟨hal-01801857⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for heavy resonances decaying into two Higgs bosons or into a Higgs boson and a W or Z boson in proton-proton collisions at 13 TeV. JHEP, 2019, 01, pp.051. ⟨10.1007/JHEP01(2019)051⟩. ⟨hal-01861894⟩

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