Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Brice Bastian, Stefan Hohenegger, Amer Iqbal, Soo-Jong Rey. Five-Dimensional Gauge Theories from Shifted Web Diagrams. Physical Review D, 2019, 99 (4), pp.046012. ⟨10.1103/PhysRevD.99.046012⟩. ⟨hal-01909171⟩
    • Rebecca Meissner, Linda Feketeová, Eugen Illenberger, Stephan Denifl. Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons. Int.J.Mol.Sci., 2019, 20 (14), pp.3496. ⟨10.3390/ijms20143496⟩. ⟨hal-02277850⟩
    • Justin H. Robinson, Misty C. Bentz, Megan C. Johnson, HĂ©lène M. Courtois, Benjamin Ou-Yang. H i Spectroscopy of Reverberation-mapped Active Galactic Nuclei. Astrophys.J., 2019, 880 (2), pp.68. ⟨10.3847/1538-4357/ab29f9⟩. ⟨hal-02447923⟩
    • M. Antonello, A. Belov, G. Bonomi, R.S. Brusa, M. Caccia, et al.. Efficient 2^3S positronium production by stimulated decay from the 3^3P level. Phys.Rev.A, 2019, 100 (6), pp.063414. ⟨10.1103/PhysRevA.100.063414⟩. ⟨hal-02166467⟩
    • Veronica Tessaro, Floriane Poignant, Benoit Gervais, MichaĂ«l Beuve, Mariel E. Galassi. Theoretical study of W-values for particle impact on water. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2019, 460, pp.259-265. ⟨10.1016/j.nimb.2018.11.031⟩. ⟨hal-01980804⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Measurement of jet radial profiles in Pb-Pb collisions at \sqrt{s_{\rm NN}}= 2.76 TeV. Physics Letters B, 2019, 796, pp.204-219. ⟨10.1016/j.physletb.2019.07.020⟩. ⟨hal-02136312⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Direct photon elliptic flow in Pb-Pb collisions at \sqrt{s_{\rm NN}} = 2.76 TeV. Physics Letters B, 2019, 789, pp.308-322. ⟨10.1016/j.physletb.2018.11.039⟩. ⟨hal-01801868⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Jaroslav Adam, Dagmar Adamova, Alexander Adler, et al.. Energy dependence of exclusive \mathrm {J}/\psi photoproduction off protons in ultra-peripheral p–Pb collisions at \sqrt{s_{\mathrm {\scriptscriptstyle NN}}} = 5.02 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.402. ⟨10.1140/epjc/s10052-019-6816-2⟩. ⟨hal-01880995⟩
    • Shreyasi Acharya, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, Jonatan Adolfsson, et al.. Coherent J/\psi photoproduction at forward rapidity in ultra-peripheral Pb-Pb collisions at \sqrt{s_{\rm{NN}}}=5.02 TeV. Physics Letters B, 2019, 798, pp.134926. ⟨10.1016/j.physletb.2019.134926⟩. ⟨hal-02129789⟩
    • Shreyasi Acharya, F.T. Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Real-time data processing in the ALICE High Level Trigger at the LHC. Comput.Phys.Commun., 2019, 242, pp.25-48. ⟨10.1016/j.cpc.2019.04.011⟩. ⟨hal-01975304⟩

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