Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Remillieux. Optiques et metrologie de VIRGO. Journee Grands Projets POPsud, Nov 2003, Sophia Antipolis, France. ⟨in2p3-00020278⟩
  • H. Hamrita, E. Rauly, Y. Blumenfeld, B. Borderie, M. Chabot, et al.. Pulse shape discrimination with silicon detectors using charge and current-sensitive preamplifiers. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.149-152. ⟨in2p3-00023393⟩
  • E. de Filippo, M. Alderighi, F. Amorini, A. Anzalone, N. Arena, et al.. Dynamical aspects of fragment productions in the reaction ^{124}Sn+^{64}Ni and ^{112}n+^{58}Ni at 35 A.MeV. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.121-127. ⟨in2p3-00023386⟩
  • J. Lukasik, W. Trautmann, G. Auger, M.L. Begemann-Blaich, N. Bellaize, et al.. INDRA@GSI : collective flow from Fermi to relativistic energies. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.66-69. ⟨in2p3-00023485⟩
  • P. Lautesse. Evolution of the fusion cross section for light systems at intermediate energies. International Winter Meeting 2003, Nov 2003, Caen, France. ⟨in2p3-00020325⟩
  • W. Trautmann, K. Turzo, C. Volant, A.S. Botvina, J. Lukasik, et al.. Multiplicity correlations in ^{12}C + ^{197}Au. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.52-57. ⟨in2p3-00023487⟩
  • E. Geraci, M. Alderighi, A. Anzalone, L. Auditore, V. Baran, et al.. Central ^{112}SN + ^{58}Ni, ^{124}Sn + ^{64}Ni collisions in the REVERSE experiment. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.139-144. ⟨in2p3-00023389⟩
  • P. Lautesse, L. Nalpas, R. Dayras, M.F. Rivet. Evolution of the fusion cross section for light systems at intermediate energies. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.213-218. ⟨in2p3-00023394⟩
  • G. Politi, M. Alderighi, F. Amorini, A. Anzalone, N. Arena, et al.. Present status of the CHIMERA-ISOSPIN experiment. International Workshop on Multifragmentation and Related Topics (IWM2003), Nov 2003, Caen, France. pp.95-101. ⟨in2p3-00023382⟩
  • Pierre-Antoine Delsart. Etude du signal H0/A0 -> tau mu aux collisionneurs hadroniques et intercalibration du calorimètre de D0 au RUN II du Tevatron. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2003. Français. ⟨NNT : ⟩. ⟨tel-00005121⟩

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