Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Gavarini, P. Trocellier, G. Matzen. Characterization of the alteration products formed at the surface of LaYSiAlO and CeYSiAlO glasses using ERDA and RBS techniques. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2004, 225, pp.364-373. ⟨10.1016/j.nimb.2004.05.042⟩. ⟨in2p3-00024612⟩
  • A. Deandrea, J. Welzel, M. Oertel. K\to \pi\nu{\bar \nu} from standard to new physics. Journal of High Energy Physics, 2004, 0410, pp.038. ⟨10.1088/1126-6708/2004/10/038⟩. ⟨in2p3-00021811⟩
  • J L. Boldo, C.P. Constantinidis, F. Gieres, M. Lefrançois, O. Piguet. Observables in topological Yang-Mills theories. International Journal of Modern Physics A, 2004, 19, pp.2971-3004. ⟨10.1142/S0217751X0401777X⟩. ⟨in2p3-00012671⟩
  • X. Artru, C. Ray. Horizontal profile of synchrotron radiation. International Workshop on Charged and Neutral Particles Channeling Phenomena "Channeling 2004", 2004, Frascati, Italy. ⟨in2p3-00024012⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Inclusive jet production in two-photon collisions at LEP. Physics Letters B, 2004, 602, pp.157-66. ⟨10.1016/j.physletb.2004.10.003⟩. ⟨in2p3-00023275⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for colour singlet and colour reconnection effects in hadronic Z decays at LEP. Physics Letters B, 2004, 581, pp.19-30. ⟨10.1016/j.physletb.2003.12.003⟩. ⟨in2p3-00021610⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Measurement of the Z-boson mass using e^+e- \to Z\gamma event at centre-of-mass energies above the Z pole. Physics Letters B, 2004, 585, pp.42-52. ⟨10.1016/j.physletb.2004.01.074⟩. ⟨in2p3-00020493⟩
  • F. Gobet, S. Eden, B. Coupier, J. Tabet, B. Farizon, et al.. Ionization of water by (20-150)-keV protons: Separation of direct-ionization and electron-capture processes. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2004, 70, pp.062716-1-8. ⟨10.1103/PhysRevA.70.062716⟩. ⟨in2p3-00023515⟩
  • R. Duffait, F. Bastien. Piezo-electric motor : Adaptation of the rotor-strator interface. Application on a 5 millimeter ravelling wave motor with longitudinal coupling of the transducers.. Actuators 2004 - 14-16 Juin 004 - Bremen, Germany,, 2004, pp. 443-446. ⟨hal-00135367⟩
  • J. Falcón-Barroso, R.F. Peletier, E. Emsellem, H. Kuntschner, K. Fathi, et al.. Formation and evolution of S0 galaxies: a SAURON case study of NGC 7332. Monthly Notices of the Royal Astronomical Society, 2004, 350, pp.35-46. ⟨10.1111/j.1365-2966.2004.07704.x⟩. ⟨in2p3-00024661⟩

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