Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • M. Martini, A. de Pace, K. Bennaceur. Spurious finite-size instabilities with Gogny-type interactions. The European physical journal. A, Hadrons and Nuclei, 2019, 55 (9), pp.150. ⟨10.1140/epja/i2019-12838-7⟩. ⟨hal-01823286⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Centrality and pseudorapidity dependence of the charged-particle multiplicity density in Xe–Xe collisions at \sqrt{s_{\rm NN}} =5.44TeV. Physics Letters B, 2019, 790, pp.35-48. ⟨10.1016/j.physletb.2018.12.048⟩. ⟨hal-01801857⟩
    • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Jonatan Adolfsson, Madan Mohan Aggarwal, et al.. Direct photon production at low transverse momentum in proton-proton collisions at \mathbf{\sqrt{s}=2.76} and 8 TeV. Physical Review C, 2019, 99 (2), pp.024912. ⟨10.1103/PhysRevC.99.024912⟩. ⟨hal-01768126⟩
    • Ehsan Kourkchi, R. Brent Tully, J. Don Neill, Mark Seibert, HĂ©lène M. Courtois, et al.. Global Attenuation in Spiral Galaxies in Optical and Infrared Bands. Astrophys.J., 2019, 884 (1), pp.82. ⟨10.3847/1538-4357/ab4192⟩. ⟨hal-02431449⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for long-lived particles using nonprompt jets and missing transverse momentum with proton-proton collisions at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 797, pp.134876. ⟨10.1016/j.physletb.2019.134876⟩. ⟨hal-02171525⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Studies of Beauty Suppression via Nonprompt D^0 Mesons in Pb-Pb Collisions at Q^2 = 4 \rm GeV^2. Phys.Rev.Lett., 2019, 123 (2), pp.022001. ⟨10.1103/PhysRevLett.123.022001⟩. ⟨hal-01921703⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for heavy resonances decaying into two Higgs bosons or into a Higgs boson and a W or Z boson in proton-proton collisions at 13 TeV. JHEP, 2019, 01, pp.051. ⟨10.1007/JHEP01(2019)051⟩. ⟨hal-01861894⟩
    • A. Adare, S. Afanasiev, C. Aidala, N.N. Ajitanand, Y. Akiba, et al.. Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions. Physical Review Letters, 2019, 123 (2), pp.022301. ⟨10.1103/PhysRevLett.123.022301⟩. ⟨hal-01801846⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Centrality and pseudorapidity dependence of the transverse energy density in pPb collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Phys.Rev.C, 2019, 100 (2), pp.024902. ⟨10.1103/PhysRevC.100.024902⟩. ⟨hal-01909251⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement and interpretation of differential cross sections for Higgs boson production at \sqrt{s} = 13 TeV. Phys.Lett.B, 2019, 792, pp.369-396. ⟨10.1016/j.physletb.2019.03.059⟩. ⟨hal-01974855⟩

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