Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- Véronique Sanglard. Latest results of the EDELWEISS experiment. Mar 2004, La Thuile. ⟨hal-00002147⟩
- Aldo Deandrea. Little Higgs and precision electroweak tests. Mar 2004, La Thuile. ⟨hal-00001559v2⟩
- D. Autiero. The OPERA event generator and the data tuning of nuclear re-interactions. 3rd International Workshop on Neutrino-Nucleus Interactions in the Few GeV Region - NuInt04, Mar 2004, Assergi, Italy. pp.253-259, ⟨10.1016/j.nuclphysbps.2004.11.168⟩. ⟨in2p3-00023977⟩
- S. Gascon-Shotkin. Electronic noise and noise treatment. CMS Workshop for Analysis and Calorimetry at H4, Mar 2004, Milan, Italy. ⟨in2p3-00024711⟩
- G.E. Brown, L. Grandchamp, C-H. Lee, M. Rho. Nature of the chiral restoration transition in QCD. Physics Reports, 2004, 391 (3-6), pp.353-361. ⟨10.1016/j.physrep.2003.10.009⟩. ⟨in2p3-00020170⟩
- M. de Jésus, D. Drain, C. Leluc, A. Masiero, J.-L. Vuillermier. Astroparticles and Cosmology. 2ème Séminaire Transalpin de Physique, Feb 2004, Dolomieu, France. pp.1-220. ⟨in2p3-00024649⟩
- J. Gascon. Direct search for WIMP dark matter. 2ème Séminaire Transalpin de Physique, Feb 2004, Dolomieu, France. pp.91-107. ⟨in2p3-00023778⟩
- S. Lapuerta. Water radiolysis effects on the corrosion of iron. 2ème Séminaire Transalpin de Physique, Feb 2004, Dolomieu, France. ⟨in2p3-00024736⟩
- B. Cochet, K. Bennaceur, P. Bonche, J. Meyer. Mean field theories of nuclei. 2ème Séminaire Transalpin, 12ème Séminaire Rhodanien "Astroparticles and Cosmology", Feb 2004, Dolomieu, France. 2004. ⟨in2p3-00024745⟩
- L. Chaussard. ROOT in the Opera Collaboration. ROOT Workshop 2004, Feb 2004, Standford, CA, United States. ⟨in2p3-00024011⟩
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