Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • F. Gobet, S. Eden, B. Coupier, J. Tabet, B. Farizon, et al.. Ionisation of water by proton and atomic hydrogen impact at velocities of the Bragg peak. Radiation Damage in Biomolecular Systems, Jun 2004, Lyon, France. ⟨in2p3-00024748⟩
  • F. Gieres, Q. Duret. Non-Hermitian Hamiltonians and supersymmetric quantum mechanics. XI International Conference on Symmetry Methods in Physics, Jun 2004, Prague, Czech Republic. ⟨in2p3-00023990⟩
  • Maurice R. Kibler. On a group-theoretical approach to the periodic table of chemical elements. Jun 2004, Prague. ⟨hal-00002554⟩
  • Benjamin Rapp. Production de dimuons en reactions p-p et Pb-Pb avec ALICE: le détecteur V0 et les résonances de basse masse. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2004. Français. ⟨NNT : ⟩. ⟨tel-00007147⟩
  • M. Floris, K. Borer, W. M. Chen, Z. Li, C. Cicalo, et al.. Charged particle multiplicity measurements in NA60. International Workshop on Particle Multiplicity In Relativistic Heavy Ion Collisions Focus on Multiplicity, Jun 2004, Bari, Italy. pp.55-63, ⟨10.1088/1742-6596/5/1/005⟩. ⟨in2p3-00024196⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, C. Baglin, et al.. Charged particle multiplicity in Pb-Pb collisions from the NA50 experiment. Focus On Multiplicity: International Workshop On Particle Multiplicity In Relativistic Heavy Ion Collisions, Jun 2004, Bari, Italy. pp.86-96, ⟨10.1088/1742-6596/5/1/008⟩. ⟨in2p3-00024210⟩
  • J. Gascon. Direct dark matter searches. XXIst International Conference on Neutrino Physics and Astrophysics - Neutrino 2004, Jun 2004, Paris, France. pp.423-428, ⟨10.1016/j.nuclphysbps.2005.01.139⟩. ⟨in2p3-00023967⟩
  • D. Autiero. Status of the OPERA experiment (CNGS1). XXIst International Conference on Neutrino Conference Physics and Astrophysics - Neutrino 2004, Jun 2004, Paris, France. pp.257-161, ⟨10.1016/j.nuclphysbps.2005.01.114⟩. ⟨in2p3-00023966⟩
  • G.-S. Muanza. Searches for Strong Dynamics at the TEVATRON. 15th International Topical Conference on Hadron Collider Physics, HCP2004, Jun 2004, East Lansing, Michigan, United States. pp.1-48. ⟨in2p3-00024798⟩
  • K. Bennaceur. Shell structure evolution far from stability : theoretical approaches. XIV Colloque GANIL, Jun 2004, Giens, France. ⟨in2p3-00025915⟩

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