Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • X. Artru. Impact parameter profile of synchrotron radiation. Nato Worskhop on Radiation by Relativistic Electrons in Periodic Structures, Aug 2004, Nor-Hamberd, Armenia. pp.387-398. ⟨in2p3-00023910⟩
  • R. Chehab. Experimental studies of positron sources using multi-GeV channelled electrons at CERN(a) and KEK(b). Nato Worskhop on Radiation by Relativistic Electrons in Periodic Structures, Aug 2004, Nor-Hamberd, Armenia. pp.357-371. ⟨in2p3-00025357⟩
  • K. Borer, W. M. Chen, Z. Li, C. Cicalo, A. de Falco, et al.. First results of the NA60 experiment at the CERN SPS. 18th Nuclear Physics Division Conference of the EPS. Phase Transitions in Strongly Interacting Matter., Aug 2004, Prague, Czech Republic. pp.251-256, ⟨10.1016/j.nuclphysa.2004.12.047⟩. ⟨in2p3-00024626⟩
  • A.B. Kurepin, B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, et al.. Transverse momentum dependence of charmonium suppression in Pb-Pb collisions at the CERN SPS. 18th Nuclear Physics Division Conference of the EPS Phase transitions in strongly interacting matter, Aug 2004, Prague, Czech Republic. pp.243c-250c, ⟨10.1016/j.nuclphysa.2004.12.046⟩. ⟨in2p3-00023924⟩
  • E. ClĂ©ment, A. Görgen, E. Bouchez, A. Chatillon, W. Korten, et al.. Shape coexistence in light krypton isotopes. Conference on Nuclei at the Limits, Jul 2004, Argonne, Illinois, United States. pp.55-61, ⟨10.1063/1.1905291⟩. ⟨in2p3-00024208⟩
  • A. Colla, R. Arnaldi, R. Averbeck, K. Banicz, K. Borer, et al.. Study of the J/\psi production and suppression in In–In collisions at the CERN SPS. Workshop for Young Scientists on the Physics of Ultra-Relativistic Nucleus-Nucleus - HOT QUARKS 2004, Jul 2004, Taos Valley, New Mexico, United States. pp.S317-S323, ⟨10.1088/0954-3899/31/4/039⟩. ⟨in2p3-00024622⟩
  • Laurent Chabert. Etude du bruit de fond neutron induit par les muons dans l'expĂ©rience EDELWEISS-II. Cosmologie et astrophysique extra-galactique [astro-ph.CO]. UniversitĂ© Claude Bernard - Lyon I, 2004. Français. ⟨NNT : ⟩. ⟨tel-00007093⟩
  • A. Drouart, J.-L. Charvet, R. Dayras, L. Nalpas, C. Volant, et al.. Evidence of Z=120 compound nucleus formation from lifetime measurement in the ^{238}U+Ni reaction at 6.62 MeV/nucleon. International Symposium on Exotic Nuclei (EXON 2004), Jul 2004, Peterhof, Russia. pp.192-197. ⟨in2p3-00024003⟩
  • M. Combescure. A mathematical study of quantum revivals and quantum fidelity. Bedlewo Conference on Operators Theory and Applications, Jul 2004, Bedlewo, Poland. pp.15. ⟨in2p3-00022208⟩
  • Carole HĂ©ritier. Identification et localisation des Ă©vĂ©nements neutrino dans le dĂ©tecteur OPERA. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2004. Français. ⟨NNT : ⟩. ⟨tel-00009860⟩

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