Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • C. Pichon. Hydrogen production during the irradiation of gaseous organic compounds: advantage of an extracted beam. 8th European Conference on Accelerators in Applied Research and Technology, Sep 2004, Paris, France. ⟨in2p3-00024737⟩
  • C. Pichon, A. Chevarier, J.-C. Duclot, A. Gardon, J.-C. Marchand, et al.. Hydrogen production during the irradiation of gaseous organic compounds: advantage of an extracted beam. Eighth European Conference on Accelerators in Applied Research and Technology (ECAART-8), Sep 2004, Paris, France. pp.589-594, ⟨10.1016/j.nimb.2005.06.229⟩. ⟨in2p3-00024645⟩
  • S. Lapuerta, N. Moncoffre, N. Millard-Pinard, E. Mendes, C. Corbel, et al.. Use of ion beam analysis techniques to characterise iron corrosion under water radiolysis. Eighth European Conference on Accelerators in Applied Research and Technology (ECAART-8), Sep 2004, Paris, France. pp.288-292, ⟨10.1016/j.nimb.2005.06.131⟩. ⟨in2p3-00024644⟩
  • H. Ohnishi, R. Arnaldi, R. Averbeck, K. Banicz, K. Borer, et al.. J/\psi production in indium–indium collisions. 8th International Conference on Strangeness in Quark Matter (SQM2004), Sep 2004, Cape Town, South Africa. pp.S1209-S1212, ⟨10.1088/0954-3899/31/6/089⟩. ⟨in2p3-00024621⟩
  • S. Damjanovic, R. Arnaldi, R. Averbeck, K. Banicz, K. Borer, et al.. First results from NA60 on low mass muon pair production in In-In collisions at 158 GeV/nucleon. 8th International Conference On Strangeness In Quark Matter (SQM2004), Sep 2004, Cape Town, South Africa. pp.S903-S910, ⟨10.1088/0954-3899/31/6/034⟩. ⟨in2p3-00024354⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, S. Beolè, et al.. J/\psi production and suppression at SPS energies. SQM2004 – 8th International Conference on Strangeness in Quark Matter, Sep 2004, Cape Town, South Africa. pp.S809-S816, ⟨10.1088/0954-3899/31/6/022⟩. ⟨in2p3-00024257⟩
  • B. Perea Solano, M.C. Abreu, V. Avati, T. Boccali, V. Boccone, et al.. Edgeless silicon pad detectors. 13th International Workshop on Vertex Detectors - VERTEX 2004, Sep 2004, Como, Italy. pp.135-138, ⟨10.1016/j.nima.2005.11.244⟩. ⟨in2p3-00071059⟩
  • F. Acernese, P. Amico, S. Aoudia, N. Arnaud, S. Avino, et al.. Virgo and the worldwide search for gravitational waves. 16th SIGRAV Conference on General Relativity and Gravitational Physics, Sep 2004, Vietri sul Mare, Italy. pp.92-100, ⟨10.1063/1.1891534⟩. ⟨in2p3-00024189⟩
  • J. Fulcher, L. Mirabito, J.A. Coughlan, G. Illes, R.J. Bainbridge, et al.. Software and DAQ for the CMS silicon tracker front end driver. 10th Workshop on Electronics for LHC and Future Experiments, Sep 2004, Boston, United States. pp.370-374. ⟨in2p3-00024725⟩
  • V. Sanglard, For The Edelweiss Collaboration. From Edelweiss-I to Edelweiss-II. Sep 2004, Edinburgh. ⟨hal-00004345⟩

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