Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Shahoyan, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. A first look at open charm production Indium-Indium collisions at SPS energies. International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions - Hard Probes 2004, Nov 2004, Ericeira, Portugal. pp.209-213, ⟨10.1140/epjc/s2005-02207-0⟩. ⟨in2p3-00024261⟩
  • G. Usai, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. Low mass dimuon production in indium-indium collisions at 158 GeV. International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions - Hard Probes 2004, Nov 2004, Ericeira, Portugal. pp.415-420, ⟨10.1140/epjc/s2005-02209-x⟩. ⟨in2p3-00024259⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, S. Beolè, et al.. The J/\psi normal nuclear absorption. International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions - HARD Probes 2004, Nov 2004, Ericeira, Portugal. pp.161-165, ⟨10.1140/epjc/s2005-02210-5⟩. ⟨in2p3-00024258⟩
  • X. Artru. Analogy between free electron laser and channeling by crystal planes. International Workshop on Charged and Neutral Particles Channeling Phenomena "Channeling 2004", Nov 2004, Rome, Italy. 597404 (7 p.). ⟨in2p3-00023911⟩
  • X. Artru, K. Beloborodov, R. Chehab, M. Chevallier, V. Shary, et al.. High intensity positron sources using channeling in crystals. International Workshop on Charged and Neutral Particles Channeling Phenomena "Channeling 2004", Nov 2004, Rome, Italy. 59740E (6 p.). ⟨in2p3-00024585⟩
  • A. Prevost, B. Rossé, M. Meyer, N. Redon, C. Schmitt, et al.. Observation of the lowest energy \gamma-ray in any superdeformed nucleus : ^{196}Bi. 2004. ⟨hal-00003090⟩
  • S. Lapuerta. Caractérisation de la corrosion du fer sous radiolyse par analyse par faisceau d'ions. 9èmes Journées de la Radiochimie/Chimie Nucléaire, Sep 2004, Arcachon, France. ⟨in2p3-00024735⟩
  • Nicolas Estre. Caractérisation des détecteurs silicium, recherche de Vertex et étude du potentiel de découverte d'un boson de Higgs chargé dans l'expérience CMS. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2004. Français. ⟨NNT : ⟩. ⟨tel-00009847⟩
  • J. Wilczynski, E. de Filippo, A. Pagano, F. Amorini, A. Anzalone, et al.. How to calibrate the time scale of emission of intermediate mass fragments. 11th Nuclear Physics Workshop, Sep 2004, Kazimierz, Poland. pp.353-357, ⟨10.1142/S0218301305003119⟩. ⟨in2p3-00025961⟩
  • S. Lapuerta. Use of ion beam analysis techniques to characterise iron corrosion. 8th European Conference on Accelerators in Applied Research and Technology, Sep 2004, Paris, France. ⟨in2p3-00024734⟩

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