Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENT MEMBERS:

NON-PERMANENT MEMBERS:

- DOCTORAL STUDENTS:
551 documents

  • M. Beuve. Hadronbiology and imaging. XVth GANIL conference, May 2006, Giens, France. ⟨hal-00994300⟩
  • Benoit Gervais, Michaël Beuve, G.H. Olivera, M.E. Galassi. Numerical simulation of multiple ionization and high LET effects in liquid water radiolysis. Radiation Physics and Chemistry, 2006, 75, pp.495-513. ⟨10.1016/j.radphyschem.2005.09.015⟩. ⟨in2p3-00409741⟩
  • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat. An Approach to Convert 4D Geometry into a 4D CT Scan. WSCG (Winter School of Computer Graphics), 2006, Plzen, Czech Republic. pp.163--170. ⟨hal-00849203⟩
  • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat. 4D CT scan Generation of Lung from Physical Simulation of Pulmonary Motion. 2nd Workshop on Computer Assisted Diagnosis and Surgery, 2006, Santiago, Chile. pp.47--50. ⟨hal-00849202⟩
  • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. A Platform for Monte Carlo Simulation of Cancer Therapy with Photon and Light Ions Beams based on the Geant 4 Toolkit. IEEE Nuclear Sciences Symposium, 2006, San Diego, USA, Unknown Region. ⟨hal-01921001⟩
  • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. ThIS : A Geant4-based Therapeutic Irradiation Simulator. 1st European Workshop on Monte Carlo Treatment Planning (MCTP), 2006, Gent, Belgium. ⟨hal-01921002⟩
  • Pierre-Frédéric Villard, Gabriel Fournier, Michaël Beuve, Behzad Shariat. Visualisation of Physical Lung Simulation: an Interactive Application to Assist Physicians. Information Visualisation, 2006, London, United Kingdom. pp.65--70. ⟨hal-00849201⟩
  • P. Jalade. Mesures et modelisation des effets radiobiologiques des ions legers sur des cellules tumorales humaines : application a l'hadrontherapie. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00012047⟩
  • M. Caron, H. Rothard, M. Toulemonde, B. Gervais, Michaël Beuve. Theoretical and experimental study of electronic temperatures in heavy ion tracks from Auger electron spectra and thermal spike calculations. Sixth Internaional Symposium on Swift Heavy Ions in Matter (SHIM 2005), May 2005, Aschaffenburg, Germany. pp.36-40, ⟨10.1016/j.nimb.2005.11.061⟩. ⟨in2p3-00416424⟩
  • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat, Vincent Baudet, Fabrice Jaillet. Lung Mesh Generation to Simulate Breathing Motion with a Finite Element Method. Information Visualisation, 2004, London, United Kingdom. pp.194--199. ⟨hal-00849206⟩

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