Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    540 documents

    • D. Dauvergne, A. Belkacem, F. BarruĂ©, J.P. Bocquet, M. Chevallier, et al.. Measurement of vacuum-assisted photoionization at 1 GeV for Au and Ag targets. Physical Review Letters, 2003, 90, pp.153002. ⟨10.1103/PhysRevLett.90.153002⟩. ⟨in2p3-00013668⟩
    • D. Dauvergne, A. Bräuning-Demian, F. Bosch, H. Bräuning, M. Chevallier, et al.. Deceleration of highly charged heavy ions in a crystal. 2003, pp.108. ⟨in2p3-00024800⟩
    • Vincent Baudet, Pierre-FrĂ©dĂ©ric Villard, Fabrice Jaillet, MichaĂ«l Beuve, Behzad Shariat. Towards Accurate Tumour Tracking in Lungs. Information Visualisation, 2003, London, United Kingdom. pp.338--343. ⟨hal-00849207⟩
    • D. Dauvergne, A. Brauening-Demian, F. Bosch, H. Brauening, M. Chevallier, et al.. Impact parameter dependent electron capture by decelerated U^{91+} ions at 20 MeV/u using crystal channeling conditions. International Conference on Highly Charged Ions, Sep 2002, Caen, France. pp.773. ⟨in2p3-00013680⟩
    • J.-P. GĂ©rard, J. Remillieux, J. Rochat, P. Jalade, M. Bajard, et al.. Projet ETOILE (Espace de Traitement Oncologique par Ions LĂ©gers dans le cadre EuropĂ©en) - Vol. 1 : Aspects mĂ©dicaux et Ă©conomiques recherches associĂ©es. 2002, pp.74. ⟨in2p3-00012341⟩
    • J.-P. GĂ©rard, J. Remillieux, J. Rochat, P. Jalade, M. Bajard, et al.. Projet ETOILE (Espace de Traitement Oncologique par Ions LĂ©gers dans le cadre Europeen) - Vol. 2 : Avant projet technique. 2002, pp.74. ⟨in2p3-00012342⟩
    • J. Remillieux. Le traitement des tumeurs par hadrontherapie. Journees d'Etudes Experimentateurs Theoriciens 5, Dec 2001, Clermont-Ferand, France. ⟨in2p3-00011676⟩
    • J. Remillieux. Carbon ion therapy : present status of the Rhone-Alpes project in Lyon. Med-AUSTRON Meeting, Dec 2001, Vienne, Austria. ⟨in2p3-00011675⟩
    • J. Remillieux. Medical applications of heavy ions beams. Colloque GANIL 13, Sep 2001, Belgodere, France. ⟨in2p3-00011674⟩
    • J. Remillieux. Projet Rhone-Alpes d'hadrontherapie par ions legers (partie scientifique). Colloque International de Radiobiologie Fondamentale et Appliquee 5, Jun 2001, Autrans, France. ⟨in2p3-00011677⟩

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