Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the t\bar{t} Production Cross Section in p\bar{p} Collisions at \sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events. Physics Letters B, 2005, 626, pp.45-54. ⟨10.1016/j.physletb.2005.08.104⟩. ⟨in2p3-00024355⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Charged particle multiplicity in three-jet events and two-gluon systems. European Physical Journal C: Particles and Fields, 2005, 44, pp.311-331. ⟨10.1140/epjc/s2005-02390-x⟩. ⟨in2p3-00024933⟩
  • Ali Al-Khatib, A.K. Singh, H. Hübel, P. Bringel, A. Bürger, et al.. High-spin states in 124Ba. Acta Physica Polonica B, 2005, 36, pp.1029-1032. ⟨in2p3-00023952⟩
  • B.M. Nyako, F. Papp, J. Gal, J. Molnar, J. Timar, et al.. Search for hyperdeformation in light Xe nuclei. Acta Physica Polonica B, 2005, 36, pp.1033-1038. ⟨in2p3-00023953⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Search for an invisibly-decaying Higgs boson at LEP. Physics Letters B, 2005, 609, pp.35-48. ⟨10.1016/j.physletb.2005.01.030⟩. ⟨in2p3-00023764⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Measurement of the Photon Structure Function F^\gamma_2 with the L3 Detector at LEP. Physics Letters B, 2005, 622, pp.249-264. ⟨10.1016/j.physletb.2005.07.028⟩. ⟨in2p3-00024385⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Measurement of exclusive \rho^+\rho^- production in mid-virtuality two-photon interactions and study of the \gamma\gamma^* \to \rho\rho process at LEP. Physics Letters B, 2005, 615, pp.19-30. ⟨10.1016/j.physletb.2005.04.011⟩. ⟨in2p3-00024138⟩
  • J. Lukasik, G. Auger, M. L. Begemann-Blaich, N. Bellaize, R. Bittiger, et al.. Directed and elliptic flow in ^{197}Au+^{197}Au at intermediate energies. Physics Letters B, 2005, 608, pp.223-230. ⟨10.1016/j.physletb.2004.12.076⟩. ⟨in2p3-00023600⟩
  • D. Autiero, Y. Déclais. Présent et futur de la physique des neutrinos auprès des accélérateurs. Comptes Rendus. Physique, 2005, 6, pp.758-767. ⟨10.1016/j.crhy.2005.07.009⟩. ⟨in2p3-00025008⟩
  • A. Novikov, M. Caroff, S. Della-Negra, J. Depauw, M. Fallavier, et al.. The Au_n cluster probe in secondary ion mass spectrometry: influence of the projectile size and energy on the desorption/ionization rate from biomolecular solids. Rapid Communications in Mass Spectrometry, 2005, 19, pp.1851-1857. ⟨10.1002/rcm.1995⟩. ⟨in2p3-00024292⟩

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