Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • G. Aldering, W. Althouse, R. Amanullah, J. Annis, P. Astier, et al.. Seeing the Nature of the Accelerating Physics: It's a SNAP. 2005. ⟨in2p3-00024783⟩
  • B. Gervais, M. Beuve, G.H. Olivera, M.E. Galassi, R.D. Rivarola. Production of HO2 and O2 by multiple ionization in water radiolysis by swift carbon ions. Chemical Physics Letters, 2005, 410, pp.330-334. ⟨10.1016/j.cplett.2005.05.057⟩. ⟨in2p3-00409801⟩
  • T. Venkova, M.G. Porquet, A. Astier, I. Deloncle, P. Petkov, et al.. New high-spin states of ^{147}Nd and ^{145}Ce: Octupole correlation in the N = 87 isotones. The European physical journal. A, Hadrons and Nuclei, 2005, 26, pp.315-319. ⟨10.1140/epja/i2005-10181-4⟩. ⟨in2p3-00025690⟩
  • M.C. Abreu, J. Astruc, C. Baglin, A. Baldit, M. Bedjidian, et al.. The production of \rho, \omega and\phi vector-mesons by protons and sulphur ions with incident momentum of 200 GeV/c per nucleon. European Physical Journal C: Particles and Fields, 2005, 44, pp.375-382. ⟨10.1140/epjc/s2005-02368-8⟩. ⟨in2p3-00025193⟩
  • Emmanuel Rozière, Philippe Turcry, Ahmed Loukili. Influence du volume de pâte et des additions sur le retrait et la fissuration des bétons autoplaçants. XXIIIes rencontres universitaires de Génie Civil, 2005, Grenoble, France. ⟨hal-01008322⟩
  • Sylvie Yotte, Manuela Salta, A. J. O'Connor, J.B. Memet, Jean-Denis Lanvin, et al.. Marine Environment Damage to Atlantic Coast Historical and transport Structures and buildings: methods of assessment and repair. Medachs Project. EUROCORR 2005, 2005, Lisbonne, Portugal. ⟨hal-01008390⟩
  • J.-P. Thomas, B. Nsouli, T. Darwish, M. Fallavier, R. Khoury, et al.. Assessment of the plasma desorption time-of-flight mass spectrometry technique for pesticide adsorption and degradation on 'as-received' treated soil samples. Rapid Communications in Mass Spectrometry, 2005, 19, pp.2379-2389. ⟨10.1002/rcm.2068⟩. ⟨in2p3-00024591⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the lifetime difference in the B_s^0 system. Physical Review Letters, 2005, 95, pp.171801. ⟨10.1103/PhysRevLett.95.171801⟩. ⟨in2p3-00024388⟩
  • V.M. Abazov, R. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. A search for the flavor-changing neutral current decay B^0_s \rightarrow \mu^+ \mu^- in p\overline{p} collisions at \sqrt{s} = 1.96 TeV with the DO detector. Physical Review Letters, 2005, 94, pp.071802-1-7. ⟨10.1103/PhysRevLett.94.071802⟩. ⟨in2p3-00023259⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the ratio of B^+ and B^0 meson lifetimes. Physical Review Letters, 2005, 94, pp.182001(1-7). ⟨10.1103/PhysRevLett.94.182001⟩. ⟨in2p3-00023288⟩

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