Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D. Thériault, A. Vallée, L. Gingras, Y. Larochelle, R. Roy, et al.. Neutron to proton ratios of quasiprojectile and midrapidity emission in the {58}Ni-{58}Ni reaction at 52 MeV/Nucleon. Physical Review C, 2005, 71, pp.014610-1-13. ⟨10.1103/PhysRevC.71.014610⟩. ⟨in2p3-00023886⟩
  • B. Alessandro, C. Alexa, R. Arnaldi, M. Atayan, S. Beolè, et al.. A new measurement of J/\psi suppression in Pb-Pb collisions at 158 GeV per nucleon. European Physical Journal C: Particles and Fields, 2005, 39, pp.335-345. ⟨10.1140/epjc/s2004-02107-9⟩. ⟨in2p3-00023808⟩
  • B. Cheynis, L. Ducroux, J.-Y. Grossiord, A. Guichard, Philippe Pillot, et al.. Radiation effects on V0 detector elements. 2005, pp.1-14. ⟨in2p3-00025210⟩
  • X. Artru, S.P. Fomin, N.F. Shul'Ga. Angular distribution of radiation by relativistic electrons in a thin crystal. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2005, 230, pp.476-482. ⟨10.1016/j.nimb.2004.12.087⟩. ⟨in2p3-00023908⟩
  • K. Bennaceur, J. Dobaczewski. Coordinate-space solution of the Skyrme-Hartree-Fock-Bogolyubov equations within spherical symmetry. The program HFBRAD (v1.0). Computer Physics Communications, 2005, 168, pp.96-122. ⟨10.1016/j.cpc.2005.02.002⟩. ⟨in2p3-00023514⟩
  • J. Welzel, D. Gherson, J. Ellis. New particle physics (in French). 2005. ⟨in2p3-00024263⟩
  • A. Bonissent, A. Ealet, P. Ferruit, G. Smadja. In-orbit calibration concept for the SNAP spectrometer. 2005. ⟨in2p3-00024796⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Photon events with missing energy in e^+e^- collisions at \sqrt{s} = 130 to 209 GeV. European Physical Journal C: Particles and Fields, 2005, 38, pp.395-411. ⟨10.1140/epjc/s2004-02051-8⟩. ⟨in2p3-00023227⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Measurement of the energy dependence of hadronic jet rates and the strong coupling \alpha_s from the four-jet rate with the DELPHI detector at LEP. European Physical Journal C: Particles and Fields, 2005, 38, pp.413-426. ⟨10.1140/epjc/s2004-02060-7⟩. ⟨in2p3-00023317⟩
  • P. Cortese, G. Dellacasa, L. Ramello, M. Sitta, N. Ahmad, et al.. ALICE Technical Design Report on Forward Detectors : FMD, T0 and V0. 2005, pp.1-76. ⟨in2p3-00024755⟩

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