Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for Higgs boson pair production in the \gamma\gamma\mathrm{b\overline{b}} final state in pp collisions at \sqrt{s}= 13 TeV. Phys.Lett.B, 2019, 788, pp.7-36. ⟨10.1016/j.physletb.2018.10.056⟩. ⟨hal-01817957⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of the Higgs boson width and anomalous HVV couplings from on-shell and off-shell production in the four-lepton final state. Phys.Rev.D, 2019, 99 (11), pp.112003. ⟨10.1103/PhysRevD.99.112003⟩. ⟨hal-01991074⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at 13 TeV. JHEP, 2019, 06, pp.143. ⟨10.1007/JHEP06(2019)143⟩. ⟨hal-02088601⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for contact interactions and large extra dimensions in the dilepton mass spectra from proton-proton collisions at \sqrt{s} = 13 TeV. JHEP, 2019, 04, pp.114. ⟨10.1007/JHEP04(2019)114⟩. ⟨hal-01975563⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Constraints on anomalous HVV couplings from the production of Higgs bosons decaying to \tau lepton pairs. Phys.Rev.D, 2019, 100 (11), pp.112002. ⟨10.1103/PhysRevD.100.112002⟩. ⟨hal-02088599⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for an exotic decay of the Higgs boson to a pair of light pseudoscalars in the final state with two muons and two b quarks in pp collisions at 13 TeV. Phys.Lett.B, 2019, 795, pp.398-423. ⟨10.1016/j.physletb.2019.06.021⟩. ⟨hal-01975266⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Thomas Bergauer, et al.. Search for supersymmetry using Higgs boson to diphoton decays at \sqrt{s} = 13 TeV. JHEP, 2019, 11, pp.109. ⟨10.1007/JHEP11(2019)109⟩. ⟨hal-02302953⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Search for a W′ boson decaying to a vector-like quark and a top or bottom quark in the all-jets final state. JHEP, 2019, 03, pp.127. ⟨10.1007/JHEP03(2019)127⟩. ⟨hal-01945206⟩
    • Simone Ferraro, Michael J. Wilson, Muntazir Abidi, David Alonso, Behzad Ansarinejad, et al.. Astro2020 Science White Paper: Inflation and Dark Energy from Spectroscopy at z > 2. Bull.Am.Astron.Soc., 2019, 51 (3), pp.72. ⟨hal-02116530⟩
    • F. Acernese, M. Agathos, L. Aiello, A. Allocca, A. Amato, et al.. Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light. Phys.Rev.Lett., 2019, 123 (23), pp.231108. ⟨10.1103/PhysRevLett.123.231108⟩. ⟨hal-02416888⟩

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