Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Shreyasi Acharya, Fernando Torales - Acosta, Jaroslav Adam, Dagmar Adamova, Alexander Adler, et al.. Energy dependence of exclusive \mathrm {J}/\psi photoproduction off protons in ultra-peripheral p–Pb collisions at \sqrt{s_{\mathrm {\scriptscriptstyle NN}}} = 5.02 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.402. ⟨10.1140/epjc/s10052-019-6816-2⟩. ⟨hal-01880995⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Charged jet cross section and fragmentation in proton-proton collisions at \sqrt{s} = 7 TeV. Physical Review D, 2019, 99 (1), pp.012016. ⟨10.1103/PhysRevD.99.012016⟩. ⟨hal-01880834⟩
  • Shreyasi Acharya, F.T. Acosta, Dagmar Adamova, Souvik Priyam Adhya, Alexander Adler, et al.. Real-time data processing in the ALICE High Level Trigger at the LHC. Computer Physics Communications, 2019, 242, pp.25-48. ⟨10.1016/j.cpc.2019.04.011⟩. ⟨hal-01975304⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Jet Shapes of Isolated Photon-Tagged Jets in Pb-Pb and pp Collisions at \sqrt{s_\mathrm{NN}} = 5.02 TeV. Physical Review Letters, 2019, 122 (15), pp.152001. ⟨10.1103/PhysRevLett.122.152001⟩. ⟨hal-01890845⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurement of the energy density as a function of pseudorapidity in proton-proton collisions at \sqrt{s} = 13 TeV. European Physical Journal C: Particles and Fields, 2019, 79 (5), pp.391. ⟨10.1140/epjc/s10052-019-6861-x⟩. ⟨hal-01965354⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. An embedding technique to determine \tau\tau backgrounds in proton-proton collision data. Journal of Instrumentation, 2019, 14 (06), pp.P06032. ⟨10.1088/1748-0221/14/06/P06032⟩. ⟨hal-02073514⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Measurements of triple-differential cross sections for inclusive isolated-photon+jet events in pp collisions at \sqrt{s} = 8\,\text {TeV}. European Physical Journal C: Particles and Fields, 2019, 79 (11), pp.969. ⟨10.1140/epjc/s10052-019-7451-7⟩. ⟨hal-02277872⟩
  • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Performance of missing transverse momentum reconstruction in proton-proton collisions at \sqrt{s} = 13 TeV using the CMS detector. Journal of Instrumentation, 2019, 14 (07), pp.P07004. ⟨10.1088/1748-0221/14/07/P07004⟩. ⟨hal-02080718⟩
  • Shreyasi Acharya, Fernando Torales - Acosta, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, et al.. Event-shape engineering for the D-meson elliptic flow in mid-central Pb-Pb collisions at \sqrt{s_{\rm NN}} =5.02 TeV. Journal of High Energy Physics, 2019, 02, pp.150. ⟨10.1007/JHEP02(2019)150⟩. ⟨hal-01897137⟩
  • Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. Study of the underlying event in top quark pair production in \mathrm {p}\mathrm {p} collisions at 13 ~\text {Te}\text {V}. European Physical Journal C: Particles and Fields, 2019, 79 (2), pp.123. ⟨10.1140/epjc/s10052-019-6620-z⟩. ⟨hal-01846639⟩

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