Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Lukasik, G. Auger, M. L. Begemann-Blaich, N. Bellaize, R. Bittiger, et al.. Directed and elliptic flow in ^{197}Au+^{197}Au at intermediate energies. Physics Letters B, 2005, 608, pp.223-230. ⟨10.1016/j.physletb.2004.12.076⟩. ⟨in2p3-00023600⟩
  • D. Autiero, Y. Déclais. Présent et futur de la physique des neutrinos auprès des accélérateurs. Comptes Rendus. Physique, 2005, 6, pp.758-767. ⟨10.1016/j.crhy.2005.07.009⟩. ⟨in2p3-00025008⟩
  • A. Novikov, M. Caroff, S. Della-Negra, J. Depauw, M. Fallavier, et al.. The Au_n cluster probe in secondary ion mass spectrometry: influence of the projectile size and energy on the desorption/ionization rate from biomolecular solids. Rapid Communications in Mass Spectrometry, 2005, 19, pp.1851-1857. ⟨10.1002/rcm.1995⟩. ⟨in2p3-00024292⟩
  • R. Barbier, S. Fleck, S. Perriès, C. Ray. Integration of information and communication technologies in special relativity teaching. European Journal of Physics, 2005, 26, pp.S13-S22. ⟨10.1088/0143-0807/26/5/S02⟩. ⟨in2p3-00024635⟩
  • A. Bartoloni, F. Cavallari, S. Costantini, I. Dafinei, M. Diemoz, et al.. CMS ECAL Barrel Channel Numbering. 2005. ⟨in2p3-00024700⟩
  • D. Kazakov, G. Smadja. Particle physics and cosmology: the interface. NATO Advanced Study Institute on Particle Physics and Cosmology: the Interface, Aug 2003, Cargese, France. Springer-Verlag, 2005. ⟨in2p3-00023958⟩
  • N. Bérerd, A. Chevarier, N. Moncoffre, P. Sainsot, H. Faust, et al.. Fission Enhanced diffusion of uranium in zirconia. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2005, 240, pp.711-718. ⟨10.1016/j.nimb.2005.04.126⟩. ⟨in2p3-00024107⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for large extra spatial dimensions in dimuon production with the D0 detector. Physical Review Letters, 2005, 95, pp.161602. ⟨10.1103/PhysRevLett.95.161602⟩. ⟨in2p3-00024307⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, D.L. Adams, et al.. Measurement of the WW production cross section in p\overline{p} collisions at \sqrt{s} = 1.96 TeV. Physical Review Letters, 2005, 94, pp.151801.1-151801.7. ⟨10.1103/PhysRevLett.94.151801⟩. ⟨in2p3-00023268⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Wb\overline{b} and WH production in p\overline{p} collisions at \sqrt{s} = 1.96 TeV. Physical Review Letters, 2005, 94, pp.091802-1-091802-7. ⟨10.1103/PhysRevLett.94.091802⟩. ⟨in2p3-00023269⟩

Powered by HAL logo