Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Seixas, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. Dimuon production in p-A and In-In collisions. 5th International Conference on Physics and Astrophysics of Quark Gluon Plasma, Feb 2005, Kolkata, India. pp.349-352, ⟨10.1088/1742-6596/50/1/046⟩. ⟨in2p3-00024269⟩
  • R. Veenhof, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. NA60 low mass di-muon data. 21st Winter Workshop on Nuclear Dynamics, Feb 2005, Breckenridge, Colorado, United States. pp.1-6. ⟨in2p3-00024295⟩
  • A. David, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. Measuring displaced muon pairs in Indium-Indium collisions at the CERN SPS. 21st Winter Workshop on Nuclear Dynamics, Feb 2005, Breckenridge, Colorado, United States. pp.1-10. ⟨in2p3-00024294⟩
  • A.B. Garnsworthy, N.J. Thompson, Zs. Podolyák, P.M. Walker, S. Williams, et al.. Spectroscopy of ^{212}Po and ^{213}At using a ^8He radioactive beam and EXOGAM. International Conference on the interface between NUclear STructure, Astrophysics and Reactions - NUSTAR 2005, Jan 2005, Guildford, United Kingdom. pp.S1851-S1854, ⟨10.1088/0954-3899/31/10/086⟩. ⟨in2p3-00024830⟩
  • P. Lautesse, A.-M. Maskay, E. Gerlic, P. DĂ©sesquelles, J.L. Laville, et al.. Experimental overview of Ni+Ni collisions at 32 MeV/nucleon: discriminant analysis and duality in the decay modes of a fusionlike system. Physical Review C, 2005, 71, pp.034602-15. ⟨10.1103/PhysRevC.71.034602⟩. ⟨in2p3-00023963⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, J. Alcaraz, G. Alemanni, et al.. Compton scattering of quasi-real virtual photons at LEP. Physics Letters B, 2005, 616, pp.145-158. ⟨10.1016/j.physletb.2005.04.054⟩. ⟨in2p3-00024174⟩
  • E. de Filippo, A. Pagano, E. Piasecki, F. Amorini, A. Anzalone, et al.. Dynamical fission in ^{124}Sn+^{64}Ni collision at 35A MeV. Physical Review C, 2005, 71, pp.064604-1-12. ⟨10.1103/PhysRevC.71.064604⟩. ⟨in2p3-00024320⟩
  • E.S. Paul, P.T.W. Choy, C. Andreoiu, A.J. Boston, A.O. Evans, et al.. Highest spin discrete levels in ^{131,132}Ce: Spin generation near the mesoscopic limit. Physical Review C, 2005, 71, 054309 (10 p.). ⟨10.1103/PhysRevC.71.054309⟩. ⟨in2p3-00024163⟩
  • R. Barbier, C. BĂ©rat, M. Besancon, M. Chemtob, A. Deandrea, et al.. R-parity-violating supersymmetry. Physics Reports, 2005, 420, pp.1-195. ⟨10.1016/j.physrep.2005.08.006⟩. ⟨in2p3-00022113⟩
  • N. Brambilla, M. Krämer, R. Mussa, A. Vairo, G. Bali, et al.. Heavy quarkonium physics. [Research Report] CERN–2005–005, CERN, Suisse. 2005, pp.1-487. ⟨in2p3-00023434⟩

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