Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Lapuerta, N. Moncoffre, N. Millard-Pinard, H. JaffrĂ©zic, N. BĂ©rerd, et al.. Role of proton irradiation and relative air humidity on iron corrosion. E-MRS 2005 Spring Meeting Symposium N on Nuclear Materials (including the 10th Inert Matrix Fuel Workshop), May 2005, Strasbourg, France. pp.174-181, ⟨10.1016/j.jnucmat.2006.02.051⟩. ⟨in2p3-00024575⟩
  • T. Duguet, K. Bennaceur, P. Bonche. Pairing schemes for HFB calculations of nuclei. Workshop on New developments in Nuclear Self-Consistent Mean-Field Theories, May 2005, Kyoto, Japan. pp.1-7. ⟨in2p3-00024562⟩
  • Philippe Pillot. Les rĂ©sonances de quarks lourds comme sonde du plasma de quarks et de gluons : optimisation du spectromètre Ă  muons de l'expĂ©rience ALICE et Ă©tude de la production du J/\psi dans l'expĂ©rience NA60. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00010685⟩
  • M. Caron, H. Rothard, M. Toulemonde, B. Gervais, MichaĂ«l Beuve. Theoretical and experimental study of electronic temperatures in heavy ion tracks from Auger electron spectra and thermal spike calculations. Sixth Internaional Symposium on Swift Heavy Ions in Matter (SHIM 2005), May 2005, Aschaffenburg, Germany. pp.36-40, ⟨10.1016/j.nimb.2005.11.061⟩. ⟨in2p3-00416424⟩
  • A. L'Hoir, A. Adoui, F. BarruĂ©, A. Billebaud, F. Bosch, et al.. Ion slowing down and charge exchange at small impact parameters selected by channeling: superdensity effects. 6th International Symposium on Swift Heavy Ions in Matter SHIM 2005, May 2005, Aschaffenburg, Germany. pp.1-14, ⟨10.1016/j.nimb.2005.11.055⟩. ⟨in2p3-00025220⟩
  • I. Baranov, S. Della-Negra, M. Fallavier, S. Kirillov, Y. Le Beyec, et al.. Sputtering and emission of nanoclusters under bombardment of gold nanodispersed targets by 1 MeV Au5 cluster ions. Sixth International Symposium on Swift Heavy Ions in Matter (SHIM 2005), May 2005, Aschaffenburg, Germany. pp.184-188, ⟨10.1016/j.nimb.2005.11.128⟩. ⟨in2p3-00025713⟩
  • M. Deile, E. Alagoz, G. Anelli, G. Antchev, M. Ayache, et al.. Tests of a Roman Pot Prototype for the TOTEM Experiment. Particle Accelerators Conference (PAC05), May 2005, Knoxville, Tennessee, United States. pp.1664-1667. ⟨in2p3-00024723⟩
  • N. BĂ©rerd, Y. Pipon, N. Moncoffre, A. Chevarier, H. Faust, et al.. Major actinide diffusion (U, Pu) in oxidised zirconium. Application to nuclear fuel cladding tubes. International Workshop on Nuclear Fission and Fission-Product, May 2005, Cadarache, France. 798, pp.345-348, 2005, ⟨10.1063/1.2137265⟩. ⟨in2p3-00024740⟩
  • S. Gascon-Shotkin. Higgs and top subgroup report. 4th Workshop : Physics at TeV Colliders, May 2005, Les Houches, France. ⟨in2p3-00024717⟩
  • S. Gascon-Shotkin. Associated Higgs production via q\bar{q} / gg \to t\bar{t} + H^0(H^0)\to \ell + \gamma\gamma + X. 4th Workshop : Physics at TeV Colliders, May 2005, Les Houches, France. ⟨in2p3-00024726⟩

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