Health (PRISME)

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  • Activities
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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Renaud Gaglione, Gérard Bohner, Jacques Lecoq, Gérard Montarou, Laurent Royer. An application specific integrated circuit for multi-anode PMT. 4th International Conference on New Developments in Photodetection - BEAUNE 2005, Jun 2005, Beaune, France. pp.118-123, ⟨10.1016/j.nima.2006.05.053⟩. ⟨in2p3-00409712⟩
  • P. Depasse, H. El Mamouni, J. Fay, S. Gascon-Shotkin, B. Ille, et al.. Final calibration results of CMS electromagnetic calorimeter photodetectors: The "Capsules". 4th International Conference on New Developments in Photodetection - BEAUNE 2005, Jun 2005, Beaune, France. pp.242-245, ⟨10.1016/j.nima.2006.05.101⟩. ⟨in2p3-00024706⟩
  • A. Deandrea, M. Ladisa, V. Laporta, G. Nardulli, P. Santorelli. Final state interactions in the B meson decay into two pions. QCD@WORK 2005: International Workshop on Quantum Chromodynamics: Theory and Experiment, Jun 2005, Conversano, Bari, Italy. pp.197-202, ⟨10.1063/1.2163763⟩. ⟨in2p3-00024565⟩
  • Philippe Pillot, R. Arnaldi, R. Avebeck, K. Banicz, J. Castor, et al.. J/\psi production in indium-indium collisions at SPS energies. QCD@Work 2005 International Workshop on Quantum Chromodynamics: Theory and Experiment, Jun 2005, Conversano, Bari, Italy. pp.279-285, ⟨10.1063/1.2163775⟩. ⟨in2p3-00025240⟩
  • B. Herskind, G.B. Hagemann, G. Sletten, T. Dossing, C.R. Hansen, et al.. Charged particle feeding of hyperdeformed nuclei in the A=118-126 region. International Conference on Finite Fermionic Systems: Nilsson Model 50 Years, Jun 2005, Lund, Sweden. pp.108-114, ⟨10.1088/0031-8949/2006/T125/025⟩. ⟨in2p3-00089281⟩
  • E.S. Paul, P.T.W. Choy, C. Andreoiu, A.J. Boston, A.O. Evans, et al.. The highest spin discrete levels in ^{131,132}Ce. International Conference on Finite Fermionic Systems Nilsson Model 50 Years, Jun 2005, Lund, Sweden. pp.115-118, ⟨10.1088/0031-8949/2006/T125/026⟩. ⟨in2p3-00086974⟩
  • M. Petri, E.S. Paul, P.J. Nolan, A.J. Boston, R.J. Cooper, et al.. Probing the maximally deformed light rare-earth region around the drip-line nucleus ^{130}Sm. International Conference on Finite Fermionic Systems: Nilsson Model 50 Years, Jun 2005, Lund, Sweden. pp.214-215, ⟨10.1088/0031-8949/2006/T125/057⟩. ⟨in2p3-00089856⟩
  • P.-E. Vert, G. Bohner, J. Lecoq, Gerard Montarou, P. Le Dû, et al.. Contribution of HEP electronics techniques to the medical imaging field. 14th IEEE-NPSS Real Time Conference 2005, Jun 2005, Stockholm, Sweden. pp.1-5. ⟨in2p3-00025444⟩
  • D. Davesne. Pion Interaction at High Temperature and Density. International Workshop on Electromagnetic Probes of Hot and Dense Matter, Jun 2005, Trento, Italy. ⟨in2p3-00406380⟩
  • G. Chanfray. Partial chiral symmetry restoration and QCD scalar susceptibilities in nuclear matter. International Workshop on Electromagnetic Probes of Hot and Dense Matter, Jun 2005, Trento, Italy. ⟨in2p3-00024692⟩

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