Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M.-H. Aumeunier, A. Ealet, E. Prieto, C. Cerna, C. Macaire, et al.. An integral field spectrograph with slicer for SNAP: Design and prototypes. Integral Field Spectroscopy: Techniques and Data Production, Jul 2005, Durham, United Kingdom. pp.285-289, ⟨10.1016/j.newar.2006.03.003⟩. ⟨in2p3-00089866⟩
  • L. Arrabito, D. Autiero, E. Barbuto, C. Bozza, S. Cecchini, et al.. Search for spontaneous muon emission from lead nuclei. 2005. ⟨in2p3-00024318⟩
  • P. O. Petrucci, Jorge Ferreira, G. Henri, L. Sauge, G. Pelletier. A multi-flow model for microquasars. Conference on High Energies in the Highlands, Jun 2005, Fort William, United Kingdom. pp.1-12. ⟨in2p3-00093711⟩
  • K. Zahraman, B. Nsouli, M. Roumié, J.-P. Thomas, S. Danel. On the optimization of the PIXE technique for thickness uniformity control of ultra-thin chromium layers deposited onto large surface quartz substrate. 17th International Conference on Ion Beam Analysis, Jun 2005, Seville, Spain. pp.447-450, ⟨10.1016/j.nimb.2006.03.028⟩. ⟨in2p3-00091030⟩
  • B. Nsouli, T. Darwish, K. Zahraman, A. Bejjani, M. Roumié, et al.. Total boron assessment in soil samples from dry Mediterranean region using the thick target-particle induced gamma-ray emission technique. 17th International Conference on Ion Beam Analysis, Jun 2005, Seville, Spain. pp.566-570, ⟨10.1016/j.nimb.2006.03.056⟩. ⟨in2p3-00091056⟩
  • N. Bérerd, N. Moncoffre, A. Chevarier, H. Jaffrézic, H. Faust, et al.. Study of the zirconium oxidation under heavy ion irradiation. Seventeenth International Conference on Ion Beam Analysis, Jun 2005, Sevilla, Spain. pp.513-516, ⟨10.1016/j.nimb.2006.03.043⟩. ⟨in2p3-00087035⟩
  • S. Lapuerta, N. Moncoffre, N. Bérerd, H. Jaffrézic, N. Millard-Pinard, et al.. Ion beam analysis of the effect of O_2 and H_2O on the oxidation of iron under irradiation. 17th International Conference on Ion Beam Analysis, Jun 2005, Seville, Spain. pp.470-473, ⟨10.1016/j.nimb.2006.03.034⟩. ⟨in2p3-00024576⟩
  • N. Moncoffre. Study of the zirconium oxidation under heavy irradiation. 17th International Conference Ion Beam Analysis, Jun 2005, Séville, Spain. 2005. ⟨in2p3-00024739⟩
  • A. Prévost, A. Astier, I. Deloncle, M.-G. Porquet, F. Azaiez, et al.. In-Beam \gamma-Ray Spectroscopy of the N=50 Isotones on the Neutron-Rich Side. International Symposium on Exotic Nuclear Systems ENS'05, Jun 2005, Debrecen, Hungary. pp.279-282, ⟨10.1063/1.2140667⟩. ⟨in2p3-00126671⟩
  • P. Depasse, H. El Mamouni, J. Fay, S. Gascon-Shotkin, B. Ille, et al.. Final calibration results of CMS electromagnetic calorimeter photodetectors: The "Capsules". 4th International Conference on New Developments in Photodetection - BEAUNE 2005, Jun 2005, Beaune, France. pp.242-245, ⟨10.1016/j.nima.2006.05.101⟩. ⟨in2p3-00024706⟩

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