Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Andriamonje, V. Arsov, S. Aune, D. Autiero, F. Avignone, et al.. Search for solar axions: the CAST experiment at CERN. Conference of the Advanced-Studies-Institute on Symmetries and Spin/Workshop on Hadron Structure and Hadron Spectroscopy, Jul 2005, Prague, Czech Republic. pp.C203-C209. ⟨in2p3-00409719⟩
  • J. Blaha, C. Combaret, J. Fay, G. Maurelli. Calibration of the very-front-end electronics for the electromagnetic calorimeter of the CMS experiment. Conference of the Advanced-Studies-Institute on Symmetries and Spin/Workshop on Hadron Structure and Hadron Spectroscopy, Jul 2005, Prague, Czech Republic. pp.C401-C408. ⟨in2p3-00409721⟩
  • H.K. Wöhri, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. Low mass dimuon production in proton-nucleus and indium-indium collisions. International Europhysics Conference on High Energy Physics HEP2005, Jul 2005, Lisboa, Portugal. pp.PoS(HEP2005)132. ⟨in2p3-00025244⟩
  • C. Lourenço, R. Averbeck, K. Banicz, J. Castor, B. Chaurand, et al.. J/\psi suppression in indium-indium collisions at SPS energies. International Europhysics Conference on High Energy Physics HEP2005, Jul 2005, Lisboa, Portugal. pp.PoS(HEP2005)133. ⟨in2p3-00025242⟩
  • R. Shaoyan, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. Intermediate mass dimuon production in indium-indium collisions at the CERN SPS. International Europhysics Conference on High Energy Physics HEP2005, Jul 2005, Lisboa, Portugal. pp.PoS(HEP2005)131. ⟨in2p3-00025243⟩
  • D. Dauvergne, M. Chevallier, J.-C. Poizat, C. Ray, A. Bräuning-Demian, et al.. Impact parameter dependent charge exchange studies with channeled heavy ions. 24th International Conference on Photonic, Electronic and Atomic Collisions ICPEAC, Jul 2005, Rosario, Argentina. pp.539-547, ⟨10.1142/9789812772442_0071⟩. ⟨in2p3-00025221⟩
  • P. Royole-Degieux. Développement d'un système de scan automatique pour la détection des particules chargées dans OPERA et séparation des pions/muons de basse énergie. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00011672⟩
  • Marie-Odile Carrère, Lionel Perrier, Pascal Pommier, J. Rochat, Luciano Zucca. A model to calculate treatment cost per protocol for light ion facility radiotherapy projects in Europe. 5th World congress of the International Health Economics Association, Barcelone, 10th-13th July, 2005, Jul 2005, Barcelona, Spain. ⟨halshs-00266174⟩
  • B. Cochet. Interactions effectives et théorie de champs moyens: de la matière nucléaire aux noyaux. Physique mathématique [math-ph]. Université Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00413527⟩
  • Y. Copin, N. Blanc, S. Bongard, E. Gangler, L. Saugé, et al.. The Nearby Supernova Factory. Integral Field Spectroscopy: Techniques and Data Production, Jul 2005, Durham, United Kingdom. pp.436-438, ⟨10.1016/j.newar.2006.02.035⟩. ⟨in2p3-00089880⟩

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