Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Philippe Turcry, Ahmed Loukili, Pierre Mounanga, Jack Legrand. Influence of limestone filler on cement hydration and chemical shrinkage at early age. Creep, Shrinkage and Durability of Concrete and Concrete Structures CONCREEP7, Sep 2005, Nantes, France. ⟨hal-01008328⟩
  • B. Rossé, N. Redon, O. Stézowski, C. Schmitt, D. Guinet, et al.. \gamma-Spectroscopy and Radioactive Beams : How To Perform Channel Selection ?. S.V. Harissopulos, P. Demetriou, E. Julin. Frontiers in Nuclear Structure, Astrophysics, and Reactions - FINUSTAR, Sep 2005, Isle of Kos, Greece. AIP Press, 831 (831), pp.541-543, 2006, AIP Conference Proceedings. ⟨10.1063/1.2201009⟩. ⟨in2p3-00087269⟩
  • J. M. Daugas, M. Sawicka, M. Pfützner, I. Matea, H. Grawe, et al.. Isomeric island in the vicinity of ^{66}Fe. S.V. Harissopulos, P. Demetriou, E. Julin. Frontiers in Nuclear Structure, Astrophysics, and Reactions - FINUSTAR, Sep 2005, Isle of Kos, Greece. 831 (831), pp.427-429, 2006, ⟨10.1063/1.2200971⟩. ⟨in2p3-00087246⟩
  • A. Prévost, A. Astier, I. Deloncle, M.-G. Porquet, F. Azaiez, et al.. Experimental Sign of a Weakening of the N=50 Spherical Shell Gap. Frontiers in Nuclear Structure, Astrophysics, and Reactions - FINUSTAR, Sep 2005, Isle of Kos, Greece. pp.538-540, ⟨10.1063/1.2201008⟩. ⟨in2p3-00123157⟩
  • H. Kraus, M. Bauer, Angélique Benoit, J. Blümer, A. Broniatowski, et al.. EURECA -- the European future of cryogenic dark matter searches. 9th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2005), Sep 2005, Zaragoza, Spain. pp.139, ⟨10.1088/1742-6596/39/1/031⟩. ⟨in2p3-00686737⟩
  • F. Gobet, S. Eden, B. Coupier, J. Tabet, B. Farizon, et al.. Biomolecular fragmentation induced by proton impact in the energy range of the Bragg peak.. 24th Miller conference on radiation chemistry, Sep 2005, La Londe les Maures, France. ⟨in2p3-00401789⟩
  • P.C.F. Di Stefano, Alain Benoit, L. Bergé, J. Blümer, A. Broniatowski, et al.. Status and outlook of the EDELWEISS experiment. 9th International Conference on Topics in Astroparticle and Underground Physics (TAUP 2005), Sep 2005, Zaragoza, Spain. pp.70, ⟨10.1088/1742-6596/39/1/015⟩. ⟨in2p3-00686766⟩
  • X. Artru, K. Benhizia. The relativistic hydrogen atom: a theoretical laboratory for structure functions. International Workshop on Transverse Polarisation Phenomena in Hard Processes, Sep 2005, Como, Italy. pp.154-161. ⟨in2p3-00025228v2⟩
  • S. Lapuerta, N. Millard-Pinard, N. Moncoffre, N. Bérerd, H. Jaffrézic, et al.. Origin of the hydrogen involved in iron corrosion under irradiation. 14th International Conference on Surface Modification of Materials by Ion Beams - SMMIB 2005, Sep 2005, Kusadasi, Turkey. pp.8197-8201, ⟨10.1016/j.surfcoat.2006.01.094⟩. ⟨in2p3-00024577⟩
  • M. de Jésus. Direct dark matter neutralino searches. XXe session Ecole prédoctorale internationale des Houches, Sep 2005, Les Houches, France. ⟨in2p3-00024650⟩

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