Health (PRISME)

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  • Activities
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  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Baret, A. Barrau, G. Boudoul, M. Buénerd, L. Derome, et al.. Flux of light antimatter nuclei near earth. 17. Particles and Nuclei International Conference (PANIC), Oct 2005, Santa Fe, NM, United States. pp.1004-1006, ⟨10.1063/1.2220440⟩. ⟨in2p3-00090084⟩
  • G. Usai, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. Results from NA60 experiment at the CERN-SPS. International Conference on Particles and Nuclei - PANIC05, Oct 2005, Santa Fe, United States. pp.29-34, ⟨10.1063/1.2220178⟩. ⟨in2p3-00025838⟩
  • Etienne Testa. Echanges de charge et perte d'énergie d'ions lourds ralentis, canalisés dans des cristaux de silicium. Physique des Hautes Energies - Expérience [hep-ex]. Université Claude Bernard - Lyon I, 2005. Français. ⟨NNT : 2005LYO10166⟩. ⟨tel-00011662⟩
  • S. Lapuerta. Etude de la corrosion du fer à l'interface de différents milieux (eau, air) soumis à l'irradiation de protons. Matériaux. Université Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00011671⟩
  • S. Bongard. Radiation transfer and type Ia Supernovae spectra analysis in the context of Supernovae factory. Astrophysics [astro-ph]. Université Claude Bernard - Lyon I; University of Oklahoma, 2005. English. ⟨NNT : ⟩. ⟨tel-00011579⟩
  • N. Wehbe, M. Fallavier. Intérêt de faisceaux primaires d'agrégats d'or pour un fort accroissement des rendements d'émission en analyse TOF-SIMS. 1er Symposium de Chimie et Biochimie Analytiques : de la molécule au protéome, Sep 2005, Montpellier, France. 2005. ⟨in2p3-00024695⟩
  • P. Russotto, E. Piasecki, F. Amorini, A. Anzalone, L. Auditore, et al.. Dynamical fission in the Sn + Ni interaction at 35A MeV. 12th Workshop on Nuclear Physics "Marie and Pierre Curie" Nuclear Structure Physics and Low Energy Reactions, Sep 2005, Kazimierz Dolny, Poland. pp.410-416, ⟨10.1142/S0218301306004284⟩. ⟨in2p3-00025941⟩
  • M. Tribet, S. Gavarini, N. Toulhoat, N. Moncoffre, A. Chevarier, et al.. Leaching of zirconolite ceramics under H^+ and He^{2+} irradiation. Migration, Sep 2005, Avignon, France. pp.585-590. ⟨in2p3-00145729⟩
  • Y. Pipon, N. Toulhoat, N. Moncoffre, H. Jaffrézic, S. Gavarini, et al.. Thermal diffusion of chlorine in uranium dioxide. Migration, Sep 2005, Avignon, France. pp.705-711, ⟨10.1524/ract.2006.94.9-11.705⟩. ⟨in2p3-00145773⟩
  • A.N. Wilson, G.D. Dracoulis, H. Hübel, P.M. Davidson, A. Korichi, et al.. Excitation energies of superdeformed states in the Pb isotopes. International Conference on Frontiers in Nuclear Structures, Astrophysics and Reactions - FINUSTAR 2005, Sep 2005, Isle of Kos, Greece. pp.373-277, ⟨10.1063/1.2200938⟩. ⟨in2p3-00147263⟩

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