Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Pierre-FrĂ©dĂ©ric Villard, Gabriel Fournier, MichaĂ«l Beuve, Behzad Shariat. Visualisation of Physical Lung Simulation: an Interactive Application to Assist Physicians. Information Visualisation, 2006, London, United Kingdom. pp.65--70. ⟨hal-00849201⟩
  • F. Gieres. Quantum theories on noncommutative space. International Meeting on Frontiers of Quantum Field Theory, 2006, Belo Horizonte, Italy. ⟨in2p3-00405846⟩
  • F. Gieres. Quantum Mechanics on noncommutative space. Operator Theory in Quantum Physics, 2006, Prague, Czech Republic. ⟨in2p3-00405851⟩
  • T. Lesinski, K. Bennaceur, T. Duguet, J. Meyer. Isovector splitting of nucleon effective masses ab initio benchmarks and extend stability criteria for Skyrme energy functionals. Physical Review C, 2006, 74, pp.044315. ⟨10.1103/PhysRevC.74.044315⟩. ⟨in2p3-00137873⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Limits on anomalous trilinear gauge couplings from WW \to e^+e^-, WW \to e^\pm e^\pm, and WW \to \mu^+\mu^- events from p\bar{p} collisions at \sqrt{s}=1.96 TeV. Physical Review D, 2006, 74, pp.057101. ⟨10.1103/PhysRevD.74.057101⟩. ⟨in2p3-00092811⟩
  • M. Lefrançois. Theories des champs topologiques et mecanique quantique en espace non-commutatif. Physique NuclĂ©aire ThĂ©orique [nucl-th]. UniversitĂ© Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00012196⟩
  • VĂ©ronique Sanglard. Recherche de la matière noire non-baryonique Ă  l'aide de dĂ©tecteurs cryogĂ©niques Ă  double composante ionisation et chaleur : Analyse et InterprĂ©tation des donnĂ©es de l'expĂ©rience EDELWEISS-I. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2005. Français. ⟨NNT : ⟩. ⟨tel-00178567⟩
  • M. Papa, F. Amorini, A. Anzalone, L. Auditore, V. Baran, et al.. Dynamical multi-break processes in the ^{124}Sn + ^{64}Ni system at 35 MeV/nucleon and CoMD-II calculation. International Workshop on Multifragmentation and related topics - IWM2005, Nov 2005, Catania, Italy. pp.399-408. ⟨in2p3-00087569⟩
  • P. Russotto, F. Amorini, A. Anzalone, L. Auditore, V. Baran, et al.. Recent progress in studying dynamical fragment production with CHIMERA. International Workshop on Multifragmentation and related topics - IWM2005, Nov 2005, Catania, Italy. pp.13-24. ⟨in2p3-00087497⟩
  • W. Zipper, J. Blicharska, A. Grzezczuk, M. Krauze, A. Stasz, et al.. Identification of ^8Be isotope in the CsI CHIMERA detector. International Workshop on Multifragmentation and related topics - IWM2005, Nov 2005, Catania, Italy. pp.115-121. ⟨in2p3-00087501⟩

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