Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • D.N. Blaschke, F. Gieres, O. Piguet, M. Schweda. A Vector Supersymmetry in Noncommutative U(1) Gauge Theory with the Slavnov Term. Journal of High Energy Physics, 2006, 05, pp.059. ⟨10.1088/1126-6708/2006/05/059⟩. ⟨in2p3-00026020⟩
  • L. Arrabito, E. Barbuto, C. Bozza, S. Buontempo, L. Consiglio, et al.. Hardware performance of a scanning system for high speed analysis of nuclear emulsions. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006, 568, pp.578-587. ⟨10.1016/j.nima.2006.06.072⟩. ⟨in2p3-00081833⟩
  • B. Rossé, O. Stezowski. Multidimensional Calibration of the EXOGAM Segmented Clover. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006, 565, pp.623-629. ⟨10.1016/j.nima.2006.05.211⟩. ⟨in2p3-00112054⟩
  • R.C. Thomas, G. Aldering, P. Antilogus, C. Aragon, S. Bailey, et al.. Nearby Supernova Factory Observations of SN 2006D: On Sporadic Carbon Signatures in Early Type Ia Supernova Spectra. The Astrophysical Journal, 2006, 654, pp.L53-L56. ⟨10.1086/510780⟩. ⟨in2p3-00128643⟩
  • J.-E. Augustin, J. Bouchez, J. Collot, Y. Déclais, D. Huss, et al.. L'avenir de la physique des neutrinos dans nos laboratoires. Société Française de Physique Journée de la division Champs et Particules La physique du neutrino : présent et futur, 2006, Lyon, France. ⟨in2p3-00111966⟩
  • Monique Combescure, Didier Robert. Quadratic Quantum Hamiltonians revisited. Cubo Mathematical Journal, 2006, 8, pp.61-66. ⟨hal-00008676⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for neutral Higgs bosons decaying to Tau pairs in p-\bar {p} collisions at \sqrt{s} = 1.96 TeV. Physical Review Letters, 2006, 97, pp.121802. ⟨10.1103/PhysRevLett.97.121802⟩. ⟨in2p3-00026005⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for squarks and gluinos in events with jets and missing transverse energy in p\bar{p} collisions at \sqrt{s}=1.96 TeV. Physics Letters B, 2006, 638, pp.119-127. ⟨10.1016/j.physletb.2006.05.030⟩. ⟨in2p3-00025988⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the CP-violation parameter of B^0 mixing and decay with p\bar{p} \to \mu\mu X data. Physical Review D, 2006, 74, pp.092001. ⟨10.1103/PhysRevD.74.092001⟩. ⟨in2p3-00092470⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for excited muons in p\bar{p} collisions at \sqrt{s} = 1.96 TeV. Physical Review D, 2006, 73, pp.111102. ⟨10.1103/PhysRevD.73.111102⟩. ⟨in2p3-00025987⟩

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