Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • R. Lemrania, M. Robinson, V.A. Kudryavtsev, M. de Jésus, G. Gerbier, et al.. Low-energy neutron propagation in MCNPX and GEANT4. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006, 560, pp.454-459. ⟨10.1016/j.nima.2005.12.238⟩. ⟨in2p3-00026023⟩
  • L. Saugé, G. Henri. On the dependence of the spectral paramaters on the observational conditions in homogeneous time dependent models of the TeV blazars. Astronomy & Astrophysics - A&A, 2006, 454, pp.L1-L4. ⟨10.1051/0004-6361:20065395⟩. ⟨in2p3-00087900⟩
  • R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, B. Chaurand, et al.. First Measurement of the \rho Spectral Function in High-Energy Nuclear Collisions. Physical Review Letters, 2006, 96, pp.162302. ⟨10.1103/PhysRevLett.96.162302⟩. ⟨in2p3-00026024⟩
  • X. Artru, C. Ray. Photon production by charged particles in narrow optical fibers. International Conference on Charged and Neutral Particles Channeling Phenomena, 2006, Frascati, Italy. pp.66340Y, ⟨10.1117/12.741922⟩. ⟨in2p3-00105499⟩
  • P. Achard, O. Adriani, M. Aguilar-Benitez, M. van den Akker, J. Alcaraz, et al.. A search for flaring very-high-energy cosmic gamma-ray sources with the L3+C muon spectrometer. Astroparticle Physics, 2006, 25, pp.298-310. ⟨10.1016/j.astropartphys.2006.03.007⟩. ⟨in2p3-00078941⟩
  • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. A Platform for Monte Carlo Simulation of Cancer Therapy with Photon and Light Ions Beams based on the Geant 4 Toolkit. IEEE Nuclear Sciences Symposium, 2006, San Diego, USA, Unknown Region. ⟨hal-01921001⟩
  • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. ThIS : A Geant4-based Therapeutic Irradiation Simulator. 1st European Workshop on Monte Carlo Treatment Planning (MCTP), 2006, Gent, Belgium. ⟨hal-01921002⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Single Intermediate Vector Boson production in e^+e^- collisions at \sqrt{s} = 183 - 209 GeV. European Physical Journal C: Particles and Fields, 2006, 45, pp.273-289. ⟨10.1140/epjc/s2005-02419-2⟩. ⟨in2p3-00025544⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Determination of the b quark mass at the M_Z scale with the DELPHI detector at LEP. European Physical Journal C: Particles and Fields, 2006, 46, pp.569-583. ⟨10.1140/epjc/s2006-02497-6⟩. ⟨in2p3-00025777⟩
  • P. Adzic, R. Alemany-Fernandez, C. B. Almeida, N. M. Almeida, G. Anagnostou, et al.. Results of the first performance tests of the CMS electromagnetic calorimeter. European Physical Journal C: Particles and Fields, 2006, 44, pp.1-10. ⟨10.1140/epjcd/s2005-02-011-3⟩. ⟨in2p3-00025231⟩

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