Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENT MEMBERS:

NON-PERMANENT MEMBERS:

- DOCTORAL STUDENTS:
551 documents

  • Djamel Dabli, Gerard Montarou, M. Beuve. A microdosimetric analysis of the Geant4 electromagnetic codes for electrons and ions using a microdosimetric concept of the proximity function. Journée Etoile, Jun 2009, Dolomieu, France. ⟨in2p3-00404175⟩
  • M.J. Bajard, C. Peaucelle. Biomolecular Cluster Irradiation System (DIAM). Particle Accelerator Conference (PAC09), May 2009, Vancouver, Canada. ⟨in2p3-00382141⟩
  • Mira Maalouf, Gersende Alphonse, Anthony Colliaux, Michaël Beuve, S Trajkovic-Bodennec, et al.. Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinomas exposed to carbon ions and x-rays. International Journal of Radiation Oncology, Biology, Physics, 2009, 1, 74, pp.200-209. ⟨hal-01437696⟩
  • D. Dauvergne, M. Battaglia, Gerard Montarou, E. Testa. New methods of real-time control imaging for ion therapy. NIRS-ETOILE Joint Symposium on Carbon Ion Therapy, Mar 2009, Lyon, France. ⟨in2p3-00363382⟩
  • M. Beuve. Modeling of RBE: Difficulties and Needs for a New Model. Symposium on Carbon Ion Radiotherapy, Mar 2009, Lyon, France. ⟨hal-00994283⟩
  • M. Maalouf, A. Gersende, A. Colliaux, M. Beuve, S. Trajkovic-Bodennec, et al.. Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-Rays. International Journal of Radiation Oncology, Biology, Physics, 2009, 74, pp.200-209. ⟨10.1016/j.ijrobp.2009.01.012⟩. ⟨in2p3-00382723⟩
  • D. Dauvergne, E. Balanzat, C. Trautmann. Swift Heavy Ions in Matter, Proceedings of the Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008). Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008), Jun 2008, Lyon, France. Elsevier, 2009, Nuclear Instruments and Methods in Physics Research Section B. ⟨in2p3-00408002⟩
  • M.-H. Richard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, et al.. Design of a Compton camera for 3D prompt-gamma imaging during ion beam therapy: a Geant4 simulation study. IEEE Nuclear Science Symposium / Medical Imaging Conference, 2009, Unknown, Unknown Region. ⟨hal-01920982⟩
  • Etienne Testa, M. Bajard, M. Chevallier, Denis Dauvergne, Fabrice Le Foulher, et al.. Dose profile monitoring with carbon ions by means of prompt-gamma measurements. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.993-996. ⟨10.1016/j.nimb.2009.02.031⟩. ⟨hal-00283936⟩
  • Michaël Beuve, Anthony Colliaux, Djamel Dabli, Denis Dauvergne, B. Gervais, et al.. Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.983-988. ⟨10.1016/j.nimb.2009.02.016⟩. ⟨in2p3-00363079⟩

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