Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    523 documents

    • Vincent Baudet, Michael Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. New Mass-Spring System Integrating Elasticity Parameters in 2D. 2007. ⟨hal-01493734⟩
    • Anne-Laure Didier, Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat. Mechanical role of pleura on lung motion during breathing. Computer Methods in Biomechanics and Biomedical Engineering, 2007, 10 (sup1), pp.155-156. ⟨10.1080/10255840701479602⟩. ⟨hal-00849199⟩
    • Anne-Laure Didier, Pierre-Frédéric Villard, Jean-Yves Bayle, Michaël Beuve, Behzad Shariat. Breathing Thorax Simulation based on Pleura Behaviour and Rib Kinematics. Information Visualisation - MediVis, 2007, Zurich, Switzerland. pp.35--40. ⟨hal-00849200⟩
    • M. Beuve. Hadronbiology and imaging. XVth GANIL conference, May 2006, Giens, France. ⟨hal-00994300⟩
    • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat. An Approach to Convert 4D Geometry into a 4D CT Scan. WSCG (Winter School of Computer Graphics), 2006, Plzen, Czech Republic. pp.163--170. ⟨hal-00849203⟩
    • Benoit Gervais, Michaël Beuve, G.H. Olivera, M.E. Galassi. Numerical simulation of multiple ionization and high LET effects in liquid water radiolysis. Radiation Physics and Chemistry, 2006, 75, pp.495-513. ⟨10.1016/j.radphyschem.2005.09.015⟩. ⟨in2p3-00409741⟩
    • Pierre-Frédéric Villard, Michaël Beuve, Behzad Shariat. 4D CT scan Generation of Lung from Physical Simulation of Pulmonary Motion. 2nd Workshop on Computer Assisted Diagnosis and Surgery, 2006, Santiago, Chile. pp.47--50. ⟨hal-00849202⟩
    • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. ThIS : A Geant4-based Therapeutic Irradiation Simulator. 1st European Workshop on Monte Carlo Treatment Planning (MCTP), 2006, Gent, Belgium. ⟨hal-01921002⟩
    • L. Guigues, D. Sarrut, N. Dufour, M.C. Ricol, E. Testa, et al.. A Platform for Monte Carlo Simulation of Cancer Therapy with Photon and Light Ions Beams based on the Geant 4 Toolkit. IEEE Nuclear Sciences Symposium, 2006, San Diego, USA, Unknown Region. ⟨hal-01921001⟩
    • Pierre-Frédéric Villard, Gabriel Fournier, Michaël Beuve, Behzad Shariat. Visualisation of Physical Lung Simulation: an Interactive Application to Assist Physicians. Information Visualisation, 2006, London, United Kingdom. pp.65--70. ⟨hal-00849201⟩

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