Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • M.L. Gallin-Martel, L. Abbassi, J.-F. Adam, S. Brambilla, A. Bes, et al.. Diamond-based detector development for medical and nuclear applications. French Japanese Workshop on Diamond Power Devices, Jan 2019, Aussois, France. ⟨hal-02349542⟩
  • A. Cerri, V.V. Gligorov, S. Malvezzi, J. Martin Camalich, J. Zupan, et al.. Opportunities in Flavour Physics at the HL-LHC and HE-LHC. 2019. ⟨hal-01975231⟩
  • Nicolas Chamel, John Michael Pearson, Alexander Y. Potekhin, Anthea F. Fantina, Camille Ducoin, et al.. Role of the Symmetry Energy on the Structure of Neutron Stars with Unified Equations of State. Xiamen-CUSTIPEN Workshop on the EOS of Dense Neutron-Rich Matter in the Era of Gravitational Wave Astronomy, Jan 2019, Xiamen, China. pp.020021, ⟨10.1063/1.5117811⟩. ⟨hal-02123345⟩
  • Ingo Tews, Jérôme Margueron, Sanjay Reddy. Constraining the properties of dense matter and neutron stars by combining nuclear physics and gravitational waves from GW170817. Xiamen-CUSTIPEN Workshop on the EOS of Dense Neutron-Rich Matter in the Era of Gravitational Wave Astronomy, Jan 2019, Xiamen, China. pp.020009, ⟨10.1063/1.5117799⟩. ⟨in2p3-02132632⟩
  • Chen Chris Gong, Noam I. Libeskind, Elmo Tempel, Quan Guo, Stefan Gottlöber, et al.. The Origin of Lopsided Satellite Galaxy Distribution in Galaxy Pairs. Monthly Notices of the Royal Astronomical Society, 2019, 488 (3), pp.3100-3108. ⟨10.1093/mnras/stz1917⟩. ⟨hal-02272667⟩
  • M. Baldo, C. Ducoin. Coupling between superfluid neutrons and superfluid protons in the elementary excitations of neutron star matter. Phys.Rev.C, 2019, 99 (2), pp.025801. ⟨10.1103/PhysRevC.99.025801⟩. ⟨hal-02008820⟩
  • Helene M. Courtois, Renee.C. Kraan-Korteweg, Alexandra Dupuy, Romain Graziani, Noam I. Libeskind. A kinematic confirmation of the hidden Vela supercluster. Monthly Notices of the Royal Astronomical Society, 2019, 490 (1), pp.L57-L61. ⟨10.1093/mnrasl/slz146⟩. ⟨hal-02327815⟩
  • H. Abdoul-Carime, Franck Rabilloud. Selective Desorption of Ethylene after Dimethyl Sulfide Reaction on Cold Gold Surface. Journal of Physical Chemistry C, 2019, 123 (3), pp.1874-1879. ⟨10.1021/acs.jpcc.8b11311⟩. ⟨hal-01998998⟩
  • Brice Bastian, Stefan Hohenegger. Dihedral Symmetries of Gauge Theories from Dual Calabi-Yau Threefolds. Physical Review D, 2019, 99 (6), pp.066013. ⟨10.1103/PhysRevD.99.066013⟩. ⟨hal-01937744⟩
  • Alexander Belyaev, Giacomo Cacciapaglia, James Mckay, Dixon Marin, Alfonso R. Zerwekh. Minimal Spin-one Isotriplet Dark Matter. Physical Review D, 2019, 99 (11), pp.115003. ⟨10.1103/PhysRevD.99.115003⟩. ⟨hal-01876356⟩

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