Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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    8790 documents

    • Konstantin Shchablo. Performance of the CMS RPC upgrade using 2D fast timing readout system. 15th Vienna Conference on Instrumentation, Feb 2019, Vienne, Austria. ⟨hal-02075408⟩
    • M. Gouzevitch. High rate, fast timing glass RPC for the high eta CMS muon detector. 15th Vienna Conference on Instrumentation, Feb 2019, Vienne, Austria. ⟨hal-02075766⟩
    • Guillaume Garillot. Étude des gerbes hadroniques dans un calorimètre Ă  grande granularitĂ© et Ă©tude du canal e+e- → HZ (Z → qq) dans les futurs collisionneurs leptoniques. Physique NuclĂ©aire ExpĂ©rimentale [nucl-ex]. UniversitĂ© de Lyon, 2019. Français. ⟨NNT : 2019LYSE1013⟩. ⟨tel-02141420⟩
    • D. Autiero. Proposal for ProtoDUNE-Double Phase (NP02) after LS2’. SPSC meeting, Jan 2019, Genève, Switzerland. ⟨in2p3-02106819⟩
    • D. Contardo. HL-LHC program and upgrades. European School in Instrumentation for Particle and Astroparticle Physics, Jan 2019, Archamps, France. ⟨hal-02063869⟩
    • M.L. Gallin-Martel, L. Abbassi, J.-F. Adam, S. Brambilla, A. Bes, et al.. Diamond-based detector development for medical and nuclear applications. French Japanese Workshop on Diamond Power Devices, Jan 2019, Aussois, France. ⟨hal-02349542⟩
    • A. Cerri, V.V. Gligorov, S. Malvezzi, J. Martin Camalich, J. Zupan, et al.. Opportunities in Flavour Physics at the HL-LHC and HE-LHC. 2019. ⟨hal-01975231⟩
    • Nicolas Chamel, John Michael Pearson, Alexander Y. Potekhin, Anthea F. Fantina, Camille Ducoin, et al.. Role of the Symmetry Energy on the Structure of Neutron Stars with Unified Equations of State. Xiamen-CUSTIPEN Workshop on the EOS of Dense Neutron-Rich Matter in the Era of Gravitational Wave Astronomy, Jan 2019, Xiamen, China. pp.020021, ⟨10.1063/1.5117811⟩. ⟨hal-02123345⟩
    • Ingo Tews, JĂ©rĂ´me Margueron, Sanjay Reddy. Constraining the properties of dense matter and neutron stars by combining nuclear physics and gravitational waves from GW170817. Xiamen-CUSTIPEN Workshop on the EOS of Dense Neutron-Rich Matter in the Era of Gravitational Wave Astronomy, Jan 2019, Xiamen, China. pp.020009, ⟨10.1063/1.5117799⟩. ⟨in2p3-02132632⟩
    • Albert M Sirunyan, Armen Tumasyan, Wolfgang Adam, Federico Ambrogi, Ece Asilar, et al.. A search for pair production of new light bosons decaying into muons in proton-proton collisions at 13 TeV. Phys.Lett.B, 2019, 796, pp.131-154. ⟨10.1016/j.physletb.2019.07.013⟩. ⟨hal-01959772⟩

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