Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Search for \eta_b in two-photon collisions at LEP II with the DELPHI detector. Physics Letters B, 2006, 634, pp.340-346. ⟨10.1016/j.physletb.2006.01.058⟩. ⟨in2p3-00025547⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Study of leading hadrons in gluon and quark fragmentation. Physics Letters B, 2006, 643, pp.147-157. ⟨10.1016/j.physletb.2006.10.040⟩. ⟨in2p3-00107079⟩
  • H. Kraus, M. Bauer, I. Bavykina, Alain Benoit, J. Blümer, et al.. EURECA — the European Future of Dark Matter Searches with Cryogenic Detectors. 7th UCLA Symposium on Sources and Detection of Dark Matter and Dark Energy in the Universe, 2006, Marina Del Rey, United States. pp.168-171, ⟨10.1016/j.nuclphysbps.2007.08.043⟩. ⟨in2p3-00203274⟩
  • Maurice Robert Kibler, Mohammed Daoud. Fractional supersymmetry and hierarchy of shape invariant potentials. Journal of Mathematical Physics, 2006, 47, pp.122108. ⟨10.1063/1.2401711⟩. ⟨in2p3-00090893v3⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. A Determination of the centre-of-mass energy at LEP2 using radiative two-fermion events. European Physical Journal C: Particles and Fields, 2006, 46, pp.295-305. ⟨10.1140/epjc/s2006-02506-x⟩. ⟨in2p3-00025759⟩
  • B. Cheynis, L. Ducroux, J.-Y. Grossiord, A. Guichard, Philippe Pillot, et al.. Radiation effects on ALICE V0 detector components. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006, 569, pp.732-736. ⟨10.1016/j.nima.2006.09.086⟩. ⟨in2p3-00114209⟩
  • S. Bongard, E. Baron, G. Smadja, D. Branch, P.H. Hauschildt. Type Ia Supernova Spectral Line Ratios as Luminosity Indicators. The Astrophysical Journal, 2006, 647, pp.513-524. ⟨10.1086/505322⟩. ⟨in2p3-00091026⟩
  • I. Baranov, S. Della-Negra, M. Fallavier, S. Kirillov, Y. Le Beyec, et al.. Sputtering and emission of nanoclusters under bombardment of gold nanodispersed targets by 1 MeV Au5 cluster ions. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2006, 245, pp.184-188. ⟨10.1016/j.nimb.2005.11.128⟩. ⟨in2p3-00406970⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of B_d mixing using opposite-side flavor tagging. Physical Review D, 2006, 74, pp.112002. ⟨10.1103/PhysRevD.74.112002⟩. ⟨in2p3-00097162⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for pair production of scalar bottom quarks in p\bar p collisions at \sqrt{s}=1.96 TeV. Physical Review Letters, 2006, 97, pp.171806. ⟨10.1103/PhysRevLett.97.171806⟩. ⟨in2p3-00111681⟩

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