Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Taverne, M. Boutemeur, A. Buthod, L. Guigues, P. Henriquet, et al.. Detector characterization for an inline PET scanner in hadrontherapy. 1st International Conference on Molecular Imaging Technology - EuroMedIm 2006, May 2006, Marseille, France. pp.396-398, ⟨10.1016/j.nima.2006.10.118⟩. ⟨in2p3-00199628⟩
  • P.-E. Vert, J. Lecoq, Gerard Montarou, N. Pauna, Baptiste Joly, et al.. Contribution of high energy physics techniques to the medical imaging field. EuroMedIm 2006, 1st European Conference on Molecular Imaging Technology, May 2006, Marseille, France. pp.396-398, ⟨10.1016/j.nima.2006.10.118⟩. ⟨in2p3-00106883⟩
  • M. Beuve. Hadronbiology and imaging. XVth GANIL conference, May 2006, Giens, France. ⟨hal-00994300⟩
  • D.-N. Blaschke, F. Gieres, O. Piguet, M. Schweda. A Vector Supersymmetry Killing the Infrared Singularity of Gauge Theories in Noncommutative Space. 5th International Conference on Mathematical Methods in Physics, Apr 2006, Rio de Janeiro, Brazil. pp.005. ⟨in2p3-00114081⟩
  • J. Marteau. Installation de capteurs intelligents pour l'acquisition à haut débit de données via le réseau Ethernet. France, Patent n° : 04 00468. 2006. ⟨in2p3-00417465⟩
  • T. Duguet, K. Bennaceur, T. Lesinski, J. Meyer. Some challenges for Nuclear Density Functional Theory. 3rd ANL/MSU/INT/JINA RIA Theory workshop, Apr 2006, Argonne, Chicago, United States. ⟨in2p3-00083535⟩
  • A. Förster, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. Latest results from NA60. International Conference on Strangeness in Quark Matter SQM2006, Mar 2006, Los Angeles, United States. pp.S51-S60, ⟨10.1088/0954-3899/32/12/S06⟩. ⟨in2p3-00086738⟩
  • G. Benzoni, F. Azaiez, S. Leoni, S. Battacharyya, R. Borcea, et al.. In-beam \gamma spectroscopy using DIC with a radioactive Ne beam. FUSION06: Reaction Mechanisms and Nuclear Structure at the Coulomb Barrier, Mar 2006, Venice, Italy. pp.49-54, ⟨10.1063/1.2338354⟩. ⟨in2p3-00116965⟩
  • D. Jacquet, J. L. Charvet, A. Chbihi, M. Chevallier, C. Cohen, et al.. Long-lived Super-Heavy Elements Evidenced Through Fission Time Measurements. FUSION06: Reaction Mechanisms and Nuclear Structure at the Coulomb Barrier, Mar 2006, Venice, Italy. pp.239-244, ⟨10.1063/1.2338384⟩. ⟨in2p3-00116969⟩
  • M. Floris, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. Low mass dimuon production in indium-indium collisions at the CERN SPS. XLI Rencontres de Moriond on QCD and High Energy Hadronic Interactions, Mar 2006, La Thuile, Italy. pp.1-4. ⟨in2p3-00086705⟩

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