Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • S. Damjanovic, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. NA60 results on the \rho spectral function in In-In collisions. International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions (Hard Probes 2006), Jun 2006, Pacific Grove, United States. pp.327-334, ⟨10.1016/j.nuclphysa.2006.11.015⟩. ⟨in2p3-00126276⟩
  • R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, B. Chaurand, et al.. J/\psi suppression in In-In collisions at 158 GeV/nucleon. 2nd International Conference on Hard and Electromagnetic Probes of High-Energy Nuclear Collisions - Hard Probes 2006, Jun 2006, Pacific Grove, United States. pp.261-268, ⟨10.1016/j.nuclphysa.2006.11.081⟩. ⟨in2p3-00131883⟩
  • N. Wehbe. Emission ionique des solides à l'impact d'agrégats Au_n^+ (n=1-9) accélérés entre 0.15 et 1.25 MeV. Physique [physics]. Université Claude Bernard - Lyon I, 2006. Français. ⟨NNT : ⟩. ⟨tel-00097671⟩
  • Y. Copin, N. Blanc, S. Bongard, E. Gangler, L. Saugé, et al.. The Nearby Supernova Factory. New Astronomy Reviews, 2006, 50, pp.436-438. ⟨10.1016/J.NEWAR.2006.02.035⟩. ⟨in2p3-00975915⟩
  • A. Ealet, E. Prieto, A. Bonissent, R. Malina, M.-H. Aumeunier, et al.. An integral field spectrograph for the SNAP mission. Space Telescopes and Instrumentation I: Optical, Infrared, and Millimeter, May 2006, Orlando, Floride, United States. pp.626533, ⟨10.1117/12.671465⟩. ⟨in2p3-00468190⟩
  • E. Pietro, A. Ealet, B. Millard, M.-H. Aumeunnier, A. Bonissent, et al.. An integral field spectrograph for SNAP. Space Telescopes and Instrumentation 2008: Optical, Infrared, and Millimeter, May 2006, Orlando, Floride, United States. pp.701019. ⟨in2p3-00468108⟩
  • A. Refregier, O. Boulade, Y. Mellier, B. Milliard, R. Pain, et al.. DUNE: The Dark Universe Explorer. SPIE symposium "Astronomical Telescopes and Instrumentation", May 2006, Orlando, United States. pp.62651Y, ⟨10.1117/12.672261⟩. ⟨hal-00129203⟩
  • R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, B. Chaurand, et al.. First measurement of the \rho spectral function in nuclear collisions. Hot Quarks 2006: Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions, May 2006, Villasimius, Italy. pp.235-241, ⟨10.1140/epjc/s10052-006-0060-2⟩. ⟨in2p3-00131869⟩
  • R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, B. Chaurand, et al.. \phi meson production in NA60. Hot Quarks 2006: Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions, May 2006, Villasimius, Italy. pp.255-260, ⟨10.1140/epjc/s10052-006-0111-8⟩. ⟨in2p3-00131890⟩
  • S. Eden, B. Coupier, J. Tabet, B. Farizon, M. Farizon, et al.. Ionization of water and biomolecules: by protons in the bragg peak energy range : separation of direct ionization and electron capture processes. International Workshop on Radiation Damage of Water, May 2006, St.Malo, France. ⟨in2p3-00401796⟩

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