Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • A. Nardulli, J. Blaha, N. Cartiglia, C. Combaret, L. Djambazov, et al.. Performance of CMS ECAL Very Front End Electronics. 12th Workshop on Electronics For LHC and Future Experiments - LECC 2006, Sep 2006, Valence, Spain. pp.174-178. ⟨in2p3-00142598⟩
  • M. Farizon. PrĂ©sentation des travaux du groupe IPM et du plateau ANAFIRE. JournĂ©e d'Ă©changes scientifiques "SantĂ©-Environnement" Ă  l'ENTPE, Sep 2006. ⟨in2p3-00401861⟩
  • G. Chanfray. In-medium hadrons and chiral symmetry. CBM Collaboration Meeting: The Physics of High Baryonic densities, Sep 2006, Strasbourg, France. ⟨in2p3-00405965⟩
  • X. Artru, K. Benhizia. The High-Z hydrogen-like atom: a model for polarized structure functions. 2nd International Conference on Quantum Electrodynamics and Statistical Physics (QEDSP2006), Sep 2006, Kharkov, Ukraine. pp.98-103. ⟨in2p3-00189823⟩
  • Y. Pipon, N. BĂ©rerd, N. Moncoffre, C. Peaucelle, N. Toulhoat, et al.. Chlorine diffusion in uranium dioxide under heavy ion irradiation. 15th International Conference on Ion Beam Modification of Materials, Sep 2006, Taormina, Italy. pp.527-531, ⟨10.1016/j.nimb.2007.01.105⟩. ⟨in2p3-00170334⟩
  • Erwan Oliviero, Mihai Lazar, A. Gardon, C. Peaucelle, A. Perrat, et al.. High energy N+ ion implantation in 4H–SiC. 15th International Conference on Ion Beam Modification of Materials, Sep 2006, Taormina, Italy. pp.265-269, ⟨10.1016/j.nimb.2007.01.256⟩. ⟨in2p3-00170330⟩
  • Yvan Caffari. CaractĂ©risation des Ă©lectrons dans l'expĂ©rience OPERA. Cosmologie et astrophysique extra-galactique [astro-ph.CO]. UniversitĂ© Claude Bernard - Lyon I, 2006. Français. ⟨NNT : ⟩. ⟨tel-00136601⟩
  • N. Wehbe, M. Fallavier, S. Della Negra. La spectromĂ©trie de masse d'ions secondaires Ă  l'impact d'agrĂ©gats d'or: Influence de la taille et de l'Ă©nergie des agrĂ©gats sur le rendement d'Ă©mission ionique de la phĂ©nylalanine. 23èmes JournĂ©es Françaises de SpectromĂ©trie de Masse, Sep 2006, Nantes, France. ⟨in2p3-00589538⟩
  • Laurent Ducroux. Etude de la production des dimuons dans les collisions In-In dans l'experience NA60 au CERN-SPS. Physique [physics]. UniversitĂ© Claude Bernard - Lyon I, 2006. ⟨tel-00284465⟩
  • C. Pichon, N. Millard-Pinard, F. Valdivieso, A. Chevarier, M. Pijolat, et al.. Effect of cobalt hydroxo-sulphide on organic material radiolysis. E-MRS 2006: Symposium N, Sep 2006, Warsaw, Poland. pp.502-509, ⟨10.1016/j.jnucmat.2007.01.100⟩. ⟨in2p3-00409069⟩

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