Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • M. Tribet, N. Toulhoat, N. Moncoffre, P. Toulhoat, C. Jegou, et al.. Enhancement of Zirconolite Dissolution Due to Water Radiolysis. XXXth Symposium on Scientific Basis for Nuclear Waste Management, Nov 2006, Boston, United States. pp.0985-NN09-04. ⟨in2p3-00397447⟩
  • Y. Pipon, N. Toulhoat, N. Moncoffre, N. Bérerd, H. Jaffrézic, et al.. Chlorine diffusion in uranium dioxide: thermal effects versus radiation enhanced effects. XXXth Symposium on Scientific Basis for Nuclear Waste Management, Nov 2006, Boston, United States. pp.0985-NN05-03. ⟨in2p3-00397433⟩
  • Caroline Pichon. Inhibition de la production d'hydrogène radiolytique dans les déchets nucléaires de type « enrobés bitumineux » :
    étude de l'interaction entre l'hydrogène et l'hydroxosulfure de cobalt. Génie des procédés. Ecole Nationale Supérieure des Mines de Saint-Etienne, 2006. Français. ⟨NNT : ⟩. ⟨tel-00148343⟩
  • M. Ericson, G. Chanfray. From QCD to nuclear matter saturation. Yukawa International Seminar 2006 (YKIS2006) -, Nov 2006, Kyoto, Japan. pp.486-494. ⟨in2p3-00135906⟩
  • R. Shahoyan, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. NA60 results on charm and intermediate mass dimuons' production in In In 158-GeV/A collisions. 19th International Conference On Ultra-Relativistic Nucleus-Nucleus Collisions: Quark Matter 2006 (QM2006), Nov 2006, Shanghai, China. pp.S1029-S1032, ⟨10.1088/0954-3899/34/8/S149⟩. ⟨in2p3-00382204⟩
  • J. Seixas, R. Arnaldi, R. Averbeck, K. Banicz, J. Castor, et al.. NA60 results on p_T spectra and the \rho spectral function in In-In collisions. 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions: Quark Matter 2006 (QM2006), Nov 2006, Shanghai, China. pp.S1023-S1027, ⟨10.1088/0954-3899/34/8/S148⟩. ⟨in2p3-00148802⟩
  • Julien Welzel. Physique de la saveur au-delà du Modèle Standard et dimensions supplémentaires. Physique mathématique [math-ph]. Université Claude Bernard - Lyon I, 2006. Français. ⟨NNT : ⟩. ⟨tel-00175294⟩
  • J. Blaha, N. Cartiglia, C. Combaret, J. Fay, W. Lustermann, et al.. Calibration and performance test of the Very-Front-End electronics for the CMS electromagnetic calorimeter. 10th Topical Seminar on Innovative Particle and Radiation Detectors, Oct 2006, Sienne, Italy. pp.168-170, ⟨10.1016/j.nuclphysbps.2007.08.002⟩. ⟨in2p3-00203248⟩
  • Nathalie Blanc. Extraction d'étoiles standard pour l'étalonnage en flux de l'instrument SNIFS dans l'expérience Nearby Supernova Factory. Astrophysique [astro-ph]. Université Claude Bernard - Lyon I, 2006. Français. ⟨NNT : ⟩. ⟨tel-00136871⟩
  • J. Fulcher, L. Mirabito, J. Coughlan, R. Bainbridge, I. Church, et al.. Recent Results on the Performance of the CMS Tracker Readout System. 12th Workshop on Electronics For LHC and Future Experiments - LECC 2006, Sep 2006, Valence, Spain. pp.187-190. ⟨in2p3-00142602⟩

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