Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    523 documents

    • E. Testa, C. Ray, N. Freud. PROCEDE ET DISPOSITIF DE MESURE EN TEMPS REEL D'UNE DOSE LOCALE LORS DU BOMBARDEMENT D'UNE CIBLE PAR DES HADRONS AU MOYEN DES GAMMA PROMPTS. France, Patent n° : FR085308. 2008. ⟨in2p3-00408435⟩
    • E Testa, M Bajard, M Chevallier, D Dauvergne, F Le Foulher, et al.. A ContrĂ´le de l’hadronthĂ©rapie. Contribution au contrĂ´le de l’hadronthĂ©rapie eta la modĂ©lisation de la dose biologique, 2008, 93, pp.139. ⟨hal-01921618⟩
    • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, et al.. Dose profile monitoring with carbon ions by means of prompt-gamma measurements. Seventh International Symposium Swift Heavy Ion in Matter - SHIM2008, 2008, Lyon, France. ⟨in2p3-00408905⟩
    • M. Beuve, G. Alphonse, M. Maalouf, A. Colliaux, P. Battiston-Montagne, et al.. Radiobiologic Parameters and Local Effect Model Predictions for Head-and-Neck Squamous Cell Carcinomas Exposed to High Linear Energy Transfer Ions. International Journal of Radiation Oncology, Biology, Physics, 2008, 71, pp.635-642. ⟨10.1016/j.ijrobp.2007.10.050⟩. ⟨in2p3-00321614⟩
    • S. Karkar, N. Pauna, E. Testa. State of art and next challenges in instrumentation for quality control in hadrontherapy centres. 2008. ⟨in2p3-00260350⟩
    • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, et al.. Monitoring the Bragg peak location of 73 MeV/u carbon ions by means of prompt Îł-ray measurements. Applied Physics Letters, 2008, 93, pp.093506. ⟨hal-01920991⟩
    • Vincent Baudet, MichaĂ«l Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. Integrating tensile parameters in 3d mass-spring system. SURGETICA 2007 Computer-Aided Medical Interventions: tools and applications, Sep 2007, ChambĂ©ry, France. ⟨hal-01493234⟩
    • M. Beuve. Modèles microdosimĂ©triques et Modèles de trace. 8th International colloquium on applied and fundamental Radiobiology, Sep 2007, La Londe Les Maures, France. ⟨hal-00994285⟩
    • Anne-Laure Didier, Pierre-FrĂ©dĂ©ric Villard, Michael Beuve, B. Shariat. Mechanical role of pleura on lung motion during breathing. XXXIIème Congrès Annuel de la SOCIÉTÉ DE BIOMÉCANIQUE, Aug 2007, Lyon, France. ⟨hal-01486866⟩
    • Vincent Baudet, Michael Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. Integrating Tensile Parameters in 3D Mass-Spring System. 2007. ⟨hal-01493738⟩

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