Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:

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8785 documents

  • Mario Alcocer-Ávila, Caterina Monini, Micaela Cunha, Étienne Testa, Michaël Beuve. Cell survival prediction in hadrontherapy with the NanOx biophysical model. Front.in Phys., 2022, 10, pp.1011063. ⟨10.3389/fphy.2022.1011063⟩. ⟨hal-04939916⟩
  • Enrique Muñoz, A. Etxebeste, Denis Dauvergne, Jean Michel Létang, David Sarrut, et al.. Imaging of polychromatic sources through Compton spectral reconstruction. Physics in Medicine and Biology, 2022, 67 (19), pp.195017. ⟨10.1088/1361-6560/ac92b9⟩. ⟨hal-03808491⟩
  • M.E. Galassi, V.B. Tessaro, B. Gervais, M. Beuve. Theoretical multiple-ionization cross sections of Ne-like molecules by light-ion impact: H2O. Physical Review A, 2022, 106 (1), pp.012823. ⟨10.1103/PhysRevA.106.012823⟩. ⟨hal-03777875⟩
  • Yasmine Ali, Lucas Auzel, Caterina Monini, Kateryna Kriachok, Jean Michel Létang, et al.. Monte Carlo simulations of nanodosimetry and radiolytic species production for monoenergetic proton and electron beams. Benchmarking of GEANT4‐DNA and LPCHEM codes. Medical Physics, 2022, 49 (5), pp.3457-3469. ⟨10.1002/mp.15609⟩. ⟨hal-03622534⟩
  • George Dedes, Jannis Dickmann, Valentina Giacometti, Simon Rit, Nils Krah, et al.. The role of Monte Carlo simulation in understanding the performance of proton computed tomography. Zeitschrift fur Medizinische Physik, 2022, 32, pp.23-38. ⟨10.1016/j.zemedi.2020.06.006⟩. ⟨hal-02920133⟩
  • Shreyasi Acharya, Dagmar Adamova, Alexander Adler, Jonatan Adolfsson, Gianluca Aglieri Rinella, et al.. Forward rapidity J/ψ production as a function of charged-particle multiplicity in pp collisions at \sqrt{s} = 5.02 and 13 TeV. Journal of High Energy Physics, 2022, 06, pp.015. ⟨10.1007/JHEP06(2022)015⟩. ⟨hal-03513264⟩
  • Nils Krah, Denis Dauvergne, Jean Michel Létang, Simon Rit, Etienne Testa. Relative stopping power resolution in time-of-flight proton CT. Physics in Medicine and Biology, 2022, 67 (16), pp.165004. ⟨10.1088/1361-6560/ac7191⟩. ⟨hal-03677847⟩
  • Paul Rocchi, Delphine Brichart-Vernos, François Lux, I. Morfin, Laurent David, et al.. A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers. Pharmaceutics, 2022, 14 (4), pp.814. ⟨10.3390/pharmaceutics14040814⟩. ⟨hal-03662053⟩
  • Carmen Villagrasa, Hans Rabus, Giorgio Baiocco, Yann Perrot, Alessio Parisi, et al.. Intercomparison of micro- and nanodosimetry Monte Carlo simulations: An approach to assess the influence of different cross-sections for low-energy electrons on the dispersion of results. Radiation Measurements, 2022, 150, pp.106675. ⟨10.1016/j.radmeas.2021.106675⟩. ⟨hal-03508915⟩
  • Marie-Thérèse Aloy, Jacqueline Sidi Boumedine, Agathe Deville, David Kryza, Arnaud Gauthier, et al.. Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma. International Journal of Nanomedicine, 2022, Volume 17, pp.6655-6673. ⟨10.2147/IJN.S390056⟩. ⟨hal-04112046⟩

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