Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • T. Akesson, R. Aleksan, B. Allanach, S. Bertolucci, A. Blondel, et al.. Towards the European strategy for particle physics: the Briefing Book. European Physical Journal C: Particles and Fields, 2007, 51, pp.421-500. ⟨10.1140/epjc/s10052-007-0318-3⟩. ⟨in2p3-00128989⟩
  • E. Testa, P.N. Abufager, F. Bosch, A. Brauning-Demain, H. Brauning, et al.. Using channeling properties for studying the impact parameter dependence of electron capture by 20 MeV/u uranium ions in a silicon crystal. Physical Review A : Atomic, molecular, and optical physics [1990-2015], 2007, 76, pp.062901. ⟨10.1103/PhysRevA.76.062901⟩. ⟨in2p3-00164198⟩
  • Y. Pipon, N. Toulhoat, N. Moncoffre, Louis Raimbault, A.M. Scheidegger, et al.. Thermal diffusion of chlorine in uranium dioxide studied by secondary ion mass spectrometry and X-ray adsorption spectroscopy. Journal of Nuclear Materials, 2007, 362, pp.416-425. ⟨10.1016/j.jnucmat.2007.01.212⟩. ⟨in2p3-00176451⟩
  • R. Arnaldi, K. Banicz, B. Chaurand, C. Cicalò, A. Colla, et al.. J/\psi production in Indium-Indium collisions at 158 GeV/nucleon. Physical Review Letters, 2007, 99, pp.132302. ⟨10.1103/PhysRevLett.99.132302⟩. ⟨in2p3-00176311⟩
  • D. Autiero, J. Aysto, A. Badertscher, L. Bezrukov, J. Bouchez, et al.. Large underground, liquid based detectors for astro-particle physics in Europe: scientific case and prospects. Journal of Cosmology and Astroparticle Physics, 2007, 11, pp.011. ⟨10.1088/1475-7516/2007/11/011⟩. ⟨in2p3-00144159⟩
  • Zhen-Yu Yin, Pierre-Yves Hicher, Ching S. Chang. Time-dependent behaviour of embankment on soft soils. International Workshop on Constitutive Modeling - Development, Implementation, Evaluation, and Application, 2007, Hong-Kong, France. ⟨hal-01009052⟩
  • Ching S. Chang, Pierre-Yves Hicher. A Constitutive Model for Granular Materials with Surface Energy Forces. 1st US-France Symposium on Computational Mechanics, 2007, Shalimar, United States. ⟨10.1061/(ASCE)0893-1321(2009)22:1(43)⟩. ⟨hal-01007730⟩
  • T. M. Aliev, A.S. Cornell, Naveen Gaur. Lepton Flavour Violation in Unparticle Physics. Physics Letters B, 2007, 657, pp.77-80. ⟨10.1016/j.physletb.2007.09.055⟩. ⟨in2p3-00150411⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Combined D0 measurements constraining the CP-violating phase and width difference in the B_s^0 system. Physical Review D, 2007, 76, pp.057101. ⟨10.1103/PhysRevD.76.057101⟩. ⟨in2p3-00132378⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Study of the decay B^{0}_{s} \to D^{(*)}_{s} D^{(*)}_{s}. Physical Review Letters, 2007, 99, pp.241801. ⟨10.1103/PhysRevLett.99.241801⟩. ⟨in2p3-00134953⟩

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