Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • T. Salbaing, L. Feketeová, Florent Calvo, B. Farizon, M. Farizon, et al.. Thermalization in a nanodroplet: H^+(CH_3OH)_n versus H^+(H_2O)_n. 13th European Conference on Atoms Molecules and Photons (ECAMP 2019), Apr 2019, Florence, Italy. ⟨in2p3-02099649⟩
    • Sylvain Pasquet, Marina Rosas Carbajal, JĂ©rĂ´me Gaillardet, Laurent Longuevergne, Marie-Claire Pierret, et al.. From CRITEX to OZCAR: Geophysical wandering accross the FrenchCritical Zone Observatorie. EGU General Assembly 2019, Apr 2019, Vienna, Austria. ⟨hal-02115194⟩
    • Ladjohounlou Riad, Alexandra Lauret, Dominique Ardail, Gersende Alphonse, Claire Rodriguez-Lafrasse. RĂ´le des effets non-ciblĂ©s dans la rĂ©ponse des cellules de cancer ORL Ă  la radiothĂ©rapie. FORUM DE LA RECHERCHE EN CANCÉROLOGIE AUVERGNE-RHĂ”NE-ALPES 2019, Apr 2019, Lyon, France. ⟨hal-02114429⟩
    • Marie-ThĂ©rèse Aloy, Jacqueline Sidi Boumedine, G. Ollier, Olivier Tillement, François Lux, et al.. Evaluation de l’effet sensibilisant des nanoparticules AGuIX® associĂ©es Ă  une irradiation photonique dans un modèle de chondrosarcome. FORUM DE LA RECHERCHE EN CANCÉROLOGIE AUVERGNE-RHĂ”NE-ALPES 2019, Apr 2019, Lyon, France. ⟨hal-02114329⟩
    • Guillaume Baulieu. Utilisation d'un rĂ©seau de neurones pour la discrimination gamma/neutron sur le dĂ©tecteur NEDA. Workshop GPU@CCIN2P3, Apr 2019, Lyon, France. ⟨in2p3-02101710⟩
    • D. Autiero. DUNE dual-phase TDR progress. Long Baseline Neutrino Committee meeting, Apr 2019, Batavia, Chicago, United States. ⟨in2p3-02107224⟩
    • Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, et al.. ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion. Cancers, 2019, 11 (4), pp.468. ⟨10.3390/cancers11040468⟩. ⟨hal-02124279⟩
    • A. Kashlinsky, Y. Ali-Haimoud, S. Clesse, J. Garcia-Bellido, L. Wyrzykowski, et al.. Electromagnetic probes of primordial black holes as dark matter. 2019. ⟨hal-02080695⟩
    • GĂ©rald Grenier. Arborescences de particules Ă©lĂ©mentaires. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard Lyon 1, 2019. ⟨tel-02133885⟩
    • S. Beauceron. CMS Search Highlights. 54th Rencontres de Moriond on QCD and High Energy Interactions, Mar 2019, La Thuile, Italy. pp.121-124. ⟨hal-02870787⟩

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