Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
544 documents

  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. Comparison of LEM (Local effect Model) and MKM (MicrodosimetricKinetic Model). Séminaire GDRMI2B-ETOILE, Feb 2010, Lyon, France. ⟨in2p3-00465424⟩
  • M. Beuve. Modélisation des effets radiobiologiques : échelles d'espace et de temps. MELUSYN - SOLEIL conférence thématique, Jan 2010, Gif-sur-Yvette, France. ⟨in2p3-00777758⟩
  • M. Testa, M. Bajard, M. Chevallier, D. Dauvergne, P. Henriquet, et al.. Real time monitoring of the Bragg-peak position in ion therapy by means of single photon detection. Radiation and Environmental Biophysics, 2010, 49, pp.337-343. ⟨10.1007/s00411-010-0276-2⟩. ⟨in2p3-00447558⟩
  • M.-H. Richard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, et al.. Design Guidelines for a Double Scattering Compton Camera for Prompt-gamma Imaging During Ion Beam Therapy: A Monte Carlo Simulation Study. IEEE Transactions on Nuclear Science, 2010, 58, pp.87-94. ⟨10.1109/TNS.2010.2076303⟩. ⟨in2p3-00527432⟩
  • M. Testa, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. Physical measurements for real time monitoring of the Bragg peak location by means of single photon detection. 12th International Workshop on Radiation Imaging Detectors, 2010, Cambridge, United Kingdom. ⟨in2p3-00778976⟩
  • E. Testa, M. Bajard, M. Chevallier, D. Dauvergne, S. Deng, et al.. Monitoring the Bragg peak location during hadrontherapy by means of a time-of-flight camera. 12th International Workshop on Radiation Imaging Detectors, 2010, Cambridge, United Kingdom. ⟨in2p3-00778932⟩
  • G. Benzoni, F. Azaiez, I. Stefan, S. Franchoo, S. Battacharyya, et al.. Study of collisions of the radioactive ^{24}Ne beam at 7.9 MeV/u on ^{208}Pb. The European physical journal. A, Hadrons and Nuclei, 2010, 45, pp.287-292. ⟨10.1140/epja/i2010-11011-4⟩. ⟨in2p3-00506044⟩
  • J. Kopyra, H. Abdoul-Carime. Dissociation of gaseous zwitterion glycine-betaine by slow electrons. The Journal of Chemical Physics, 2010, 132, pp.204302. ⟨10.1063/1.3436718⟩. ⟨in2p3-00492921⟩
  • M. Beuve, D. Dauvergne, Gerard Montarou, C. Rodriguez-Lafrasse, E. Testa. Experimental and theoretical evaluation of the local effect model. MICROS 2009, 15th International Symposium on Microdosimetry, Oct 2009, Verone, Italy. ⟨in2p3-00533993⟩
  • Djamel Dabli, Gerard Montarou, M. Beuve, C. Rodriguez-Lafrasse. Application of the microdisimetric kinetic model to evaluate the dose-effect relation for head and neck squamous carcinoma cells exposed to high-lET ions. MICROS 2009 - 15th International Symposium on Microdosimetry, Oct 2009, Verone, Italy. ⟨in2p3-00429602⟩

Powered by HAL logo