Health (PRISME)

  • Presentation
  • Activities
  • Members
  • Publications

The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:
    523 documents

    • M.-H. Richard, M. Chevallier, D. Dauvergne, N. Freud, P. Henriquet, et al.. Design of a Compton camera for 3D prompt-gamma imaging during ion beam therapy: a Geant4 simulation study. IEEE Nuclear Science Symposium / Medical Imaging Conference, 2009, Unknown, Unknown Region. ⟨hal-01920982⟩
    • D. Dauvergne, E. Balanzat, C. Trautmann. Swift Heavy Ions in Matter, Proceedings of the Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008). Seventh International Symposium on Swift Heavy Ions in Matter (SHIM 2008), Jun 2008, Lyon, France. Elsevier, 2009, Nuclear Instruments and Methods in Physics Research Section B. ⟨in2p3-00408002⟩
    • M. Maalouf, A. Gersende, A. Colliaux, M. Beuve, S. Trajkovic-Bodennec, et al.. Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-Rays. International Journal of Radiation Oncology, Biology, Physics, 2009, 74, pp.200-209. ⟨10.1016/j.ijrobp.2009.01.012⟩. ⟨in2p3-00382723⟩
    • Anne-Laure Didier, Pierre-Frédéric Villard, Jacques Saadé, Jean-Michel Moreau, Michaël Beuve, et al.. A chest wall model based on rib kinematics. 6th International Conference on Biomedical Visualization, 2009, Barcelona, Spain. ⟨hal-00849198⟩
    • M. Bajard, M. Chevallier, D. Dauvergne, F. Le Foulher, N. Freud, et al.. Target influence on real time monitoring of the Bragg peak location by means of single photon detection. PTCOG: Particle Therapy Co-Operative Group 48, 2009, Unknown, Unknown Region. ⟨hal-01920983⟩
    • M. Testa, M. Bajard, M. Chevallier, D. Dauvergne, N. Freud, et al.. A novel technique for real time monitoring of the Bragg-peak position in ion therapy by means of single photon detection. Heavy Ions in Therapy and Space Symposium, 2009, Unknown, Unknown Region. ⟨hal-01920986⟩
    • M.-C. Ricol. Contribution à l'étude des processus nucléaires intervenant en hadronthérapie et de leur impact sur la délocalisation du dépôt de dose. Physique Nucléaire Théorique [nucl-th]. Université Claude Bernard - Lyon I, 2008. Français. ⟨NNT : ⟩. ⟨tel-00413280⟩
    • M. Beuve, Djamel Dabli, Z. Francis, Gerard Montarou. Calculation of the physical proximity function t(x) for electrons, protons and carbon ions using Geant4.. 36th annual meeting of the European Radiation Research Society (ERR 2008), Sep 2008, Tours, France. ⟨10.1051/radiopro:2008661⟩. ⟨in2p3-00337141⟩
    • Michael Beuve, C. Rodriguez-Lafrasse. In Response to Scholz et al.. International Journal of Radiation Oncology, Biology, Physics, 2008, 72 (1), pp.303. ⟨hal-00994308⟩
    • Michael Beuve, A. Colliaux, Djamel Dabli, D. Dauvergne, B. Gervais, et al.. Statistical effects of dose deposition in track-structure modeling of radiobiology efficiency. The Seventh International Symposium on Swift Heavy Ions in Matter, Jun 2008, Lyon, France. pp.983-988, ⟨10.1016/j.nimb.2009.02.016⟩. ⟨hal-00275539⟩

    Powered by HAL logo