Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Yves Caniou, Eddy Caron, Helene M. Courtois, Benjamin Depardon, Romain Teyssier. Cosmological Simulations using Grid Middleware. Fourth High-Performance Grid Computing Workshop (HPGrid'07), Mar 2007, Long Beach, United States. ⟨hal-01429585⟩
  • M. Luca. Cryogenic detectors for the EDELWEISS dark matter search. 11th International Vienna Conference on Instrumentation - VCI 2007, Feb 2007, Vienna, Austria. pp.136-138, ⟨10.1016/j.nima.2007.07.048⟩. ⟨in2p3-00235437⟩
  • G. Chanfray. Medium modifications of hadrons in dense nuclear and hadronic matter. International School on Quark-Gluon-Plasma and Heavy Ion Collisions: past, present and future, Feb 2007, Turin, Italy. ⟨in2p3-00405968⟩
  • Vincent Baudet, Michael Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. Integrating Tensile Parameters in 3D Mass-Spring System. 2007. ⟨hal-01493738⟩
  • Vincent Baudet, Michael Beuve, Fabrice Jaillet, B. Shariat, Florence Zara. New Mass-Spring System Integrating Elasticity Parameters in 2D. 2007. ⟨hal-01493734⟩
  • C. Agodi, E. de Filippo, A. Pagano, E. Piasecki, P. Russotto, et al.. A preliminary study on ternary fission in the ^{124}Sn + ^{64}Ni reaction at 35 MeV/A. XLV International Winter Meeting on Nuclear Physics, Jan 2007, Bormio, Italy. pp.243-248. ⟨in2p3-00167695⟩
  • James Brau, Yasuhiro Okada, Nicholas J Walker, Abdelhak Djouadi, Joseph Lykken, et al.. International Linear Collider Reference Design Report. [Research Report] ILC. 2007, 778 p. ⟨in2p3-00188665⟩
  • J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Search for a fourth generation b'-quark at LEP-II at sqrt{s}= 196 209 GeV. European Physical Journal C: Particles and Fields, 2007, 50, pp.507-518. ⟨10.1140/epjc/s10052-007-0273-z⟩. ⟨in2p3-00142599⟩
  • R. Tieulent, A. Béteille, J.-Y. Grossiord, V. Kakoyan, S. Kox, et al.. Results from the test bench of the Geometry Monitoring System of the ALICE Muon Spectrometer. 2007, 13 p. ⟨in2p3-00193682⟩
  • N. Le Neindre, Eric Bonnet, J.P. Wieleczko, B. Borderie, F. Gulminelli, et al.. Yield scaling, size hierarchy and fluctuations of observables in fragmentation of excited heavy nuclei. Nuclear Physics A, 2007, 795, pp.47-69. ⟨10.1016/j.nuclphysa.2007.08.011⟩. ⟨in2p3-00171092v2⟩

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