Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • P. Cortese, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. Latest results from NA60. International Europhysics Conference On High Energy Physics (EPS-HEP2007), Jul 2007, Manchester, United Kingdom. pp.032007, ⟨10.1088/1742-6596/110/3/032007⟩. ⟨in2p3-00382186⟩
  • C. Schmitt, A. Heinz, B. Jurado, A. Kelic, K.-H. Schmidt. Nuclear dissipation via peripheral collisions with relativistic radioactive actinides beams. International Symposium on Exotic Nuclei, Jul 2007, Khanty-Mansiysk, Russia. pp.342-353, ⟨10.1063/1.2746611⟩. ⟨in2p3-00409699⟩
  • M. Farizon, B. Farizon, S. Ouaskit, T. Märk. Fragment size distributions and caloric curve in collision induced cluster fragmentation. Dynamics and Thermodynamics of Systems with Long-range Interactions: Theory and Experiments, Jul 2007, Assisi (Perugia), Italy. pp.165-174, ⟨10.1063/1.2839118⟩. ⟨in2p3-00401770⟩
  • Y. Copin. The Nearby Supernova Factory: toward a high-precision spectro-photometry. Semaine de l'Astrophysique Française (SF2A 2007), Jul 2007, Grenoble, France. ⟨in2p3-00171065⟩
  • C. Buton, Y. Copin, E. Gangler, G. Smadja, E. Pecontal, et al.. The Supernovae Integral Field Spectrograph: keys to high-precision spectro-photometry. Semaine de l'Astrophysique Française (SF2A 2007), Jul 2007, Grenoble, France. Société Française d'Astronomie et d'Astrophysique, 2007. ⟨in2p3-00171064⟩
  • Y. Copin, C. Buton, E. Gangler, G. Smadja, E. Pecontal, et al.. The Nearby Supernova Factory: toward a high-precision spectro-photometry. Semaine de l'Astrophysique Française (SF2A 2007), Jul 2007, Grenoble, France. ⟨in2p3-00409066⟩
  • B. Farizon. Présentation D'ANAFIRE Plateau Technologique de l'IPN de Lyon “ Analyse et Faisceaux d'Ions pour La Radiobiologie et l'Environnement. JOURNEES PROJET de l'IN2P3, Jul 2007. ⟨in2p3-00401866⟩
  • G. Boudoul. The CMS Tracker End-Caps integration. 8th International Conference on Large Scale Applications and Radiation Hardness of Semiconductor Detectors, Jun 2007, Firenze, Italy. pp.13-16, ⟨10.1016/j.nima.2008.07.128⟩. ⟨in2p3-00355248⟩
  • T. Suwada, M. Satoh, T. Sugimura, T. Kamitani, K. Furukawa, et al.. Enhancement of the Positron Intensity by a Tungsten Single Crystal Target at the KEKB Injector Linac. 22nd Particle Accelerator Conference (PAC'07), Jun 2007, Albuquerque, New Mexico, United States. Joint Accelerator Conferences Website; IEEE, pp.2778-2780, 2007. ⟨in2p3-00169472⟩
  • M. Floris, R. Arnaldi, K. Banicz, J. Castor, B. Chaurand, et al.. Results on the intermediate mass region and on phi production from the NA60 experiment. SQM 2007- International Conference on Srangeness in Quark Matter, Jun 2007, Levoca, Slovakia. pp.044036, ⟨10.1088/0954-3899/35/4/044036⟩. ⟨in2p3-00265813⟩

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