Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • B. Abbott, A. Baranovski, M. Diesburg, G. Garzoglio, T. Kurca, et al.. DZero data-intensive computing on the Open Science Grid. International Conference on Computing in High Energy and Nuclear Physics (CHEP07), Sep 2007, Victoria, Canada. pp.062001, ⟨10.1088/1742-6596/119/6/062001⟩. ⟨in2p3-00250685⟩
  • M. Beuve. Modèles microdosimétriques et Modèles de trace. 8th International colloquium on applied and fundamental Radiobiology, Sep 2007, La Londe Les Maures, France. ⟨hal-00994285⟩
  • Anne-Laure Didier, Pierre-Frédéric Villard, Michael Beuve, B. Shariat. Mechanical role of pleura on lung motion during breathing. XXXIIème Congrès Annuel de la SOCIÉTÉ DE BIOMÉCANIQUE, Aug 2007, Lyon, France. ⟨hal-01486866⟩
  • Pierre Toulhoat, O. Grosso, N. Toulhoat, N. Moncofre. Isotopic exchange and migration of dose determining nuclides. Migration 2007, Aug 2007, Munich, Germany. ⟨ineris-00970294⟩
  • M. Tribet, N. Toulhoat, N. Moncofre, C. Jegou, G. Leturcq, et al.. Leaching of a zirconolite ceramic waste-form under proton and HE2+ irradiation. Migration 2007, Aug 2007, Munich, Germany. ⟨ineris-00970295⟩
  • Sacha Davidson. Neutrinos in Cosmology. 9th International Workshop on Neutrino Factories, Superbeams and Betabeams, Aug 2007, Okayama, Japan. pp.70-74, ⟨10.1063/1.2899004⟩. ⟨in2p3-00409696⟩
  • T. Lesinski, M. Bender, K. Bennaceur, T. Duguet, J. Meyer. The tensor part of the Skyrme energy density functional. I. Spherical nuclei. Physical Review C, 2007, 76, pp.014312. ⟨10.1103/PhysRevC.76.014312⟩. ⟨hal-00140169v4⟩
  • Gerald Grenier. Search for supersymmetric charged Higgs bosons at the TeVatron. 15th international Conference on Supersymmetry and the Unification of fundamental Interactions - SUSY 2007, Jul 2007, Karlsruhe, Germany. pp.420-424. ⟨in2p3-00176554⟩
  • P. Di Stefano, N. Coron, P. de Marcillac, C. Dujardin, M. Luca, et al.. The SciCryo Project and Cryogenic Scintillation of Al_2O_3 for Dark Matter. 12th International Workshop on Low Temperature Detectors (LTD12), Jul 2007, Paris, France. pp.902-907, ⟨10.1007/s10909-008-9759-9⟩. ⟨in2p3-00269178⟩
  • M. Luca. Sapphire scintillation tests for cryogenic detectors in the EDELWEISS dark matter search. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 2007. English. ⟨NNT : ⟩. ⟨tel-00182326⟩

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