Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Patrice Verdier. Recherche des squarks et des gluinos dans l'exeperience D0 au RunIIa du Tevatron. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2007. ⟨tel-00341558⟩
  • Jean Tabet. Irradiation de molĂ©cules biologiques (bases de l'ADN et de l'ARN) par impact de protons dans le domaine de vitesse du pic de Bragg (20-150 keV/uma). Physique [physics]. UniversitĂ© Claude Bernard - Lyon I, 2007. Français. ⟨NNT : ⟩. ⟨tel-00341551⟩
  • Kais Manai. Identification des particules par les Ă©mulsions nuclĂ©aires dans OPERA. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I; Universite Tunis El-Manar, 2007. Français. ⟨NNT : ⟩. ⟨tel-00283274⟩
  • M. Combescure. Circulant matrices, gauss sums and mutually unbiased I. The prime number case. 2007. ⟨in2p3-00184035⟩
  • David Gherson. Gravitino dans l'Univers primordial : un modèle d'extra-dimension et de matière noire. Physique mathĂ©matique [math-ph]. UniversitĂ© Claude Bernard - Lyon I, 2007. Français. ⟨NNT : ⟩. ⟨tel-00283293⟩
  • T. Kurca. Grid computing at the D0 experiment. 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC 2007), Oct 2007, Hononlulu, United States. ⟨in2p3-01234294⟩
  • S. Callier, F. Dulucq, C. de La Taille, G. Martin-Chassard, N. Seguin-Moreau, et al.. HARDROC1, readout chip of the Digital HAdronic CALorimeter of ILC. IEEE Nuclear Science Symposium/Medical Imaging Conference, Oct 2007, Honolulu, United States. pp.1851-1856, ⟨10.1109/NSSMIC.2007.4436518⟩. ⟨in2p3-00415894⟩
  • Luisa Arrabito. Developpement d'un systeme ultra rapide pour le scan des emulsions nucleaires d'OPERA et etude sur la localistion des vertex de l'interaction des neutrinos a l'aide de ce systeme. Physique des Hautes Energies - ExpĂ©rience [hep-ex]. UniversitĂ© Claude Bernard - Lyon I, 2007. Français. ⟨NNT : ⟩. ⟨tel-00283267⟩
  • Caroline Pichon, Michèle Pijolat, Nathalie Millard-Pinard, Alain Chevarier, Pascal Leverd. Etude de l'interaction entre l'hydroxosulfure de cobalt et l'hydrogène. XI° Congrès de la SociĂ©tĂ© Française de GĂ©nie des ProcĂ©dĂ©s. Des rĂ©ponses industrielles pour une sociĂ©tĂ© en mutation., Oct 2007, Saint Etienne, France. pp.ISBN=2-910239-70-5. ⟨hal-00457745⟩
  • R. Barbier, P. Depasse, J. Baudot, W. Dulinski, M. Winter, et al.. First results from the Development of a New Generation of Hybrid Photon Detectors: EBCMOS. 10th Conference Astroparticle, Particle And Space Physics, Detectors And Medical Physics Applications, Oct 2007, Como, Italy. pp.23-27. ⟨in2p3-00407708⟩

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