Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Study of direct CP violation in B^{\pm} \to J/\psi K^{\pm}(\pi^{\pm}) decays. Physical Review Letters, 2008, 100, pp.211802. ⟨10.1103/PhysRevLett.100.211802⟩. ⟨in2p3-00258748⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for long-lived particles decaying into electron or photon pairs with the D0 detector. Physical Review Letters, 2008, 101, pp.111802. ⟨10.1103/PhysRevLett.101.111802⟩. ⟨in2p3-00289673⟩
  • David Sarrut, Bertrand Delhay, Pierre-Frédéric Villard, Vlad Boldea, Michael Beuve, et al.. A Comparison Framework for Breathing Motion Estimation Methods From 4-D Imaging. IEEE Transactions on Medical Imaging, 2007, 26 (12), pp.1636-1648. ⟨10.1109/TMI.2007.901006⟩. ⟨hal-00973183⟩
  • Sacha Davidson. La leptogénèse savoureuse. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 2007. ⟨tel-00409545⟩
  • Philippe Di Stefano. A la recherche de la matière perdue. High Energy Physics - Experiment [hep-ex]. Université Claude Bernard - Lyon I, 2007. ⟨tel-00347477⟩
  • T. Duguet, P. Bonche, P. -H. Heenen, J. Meyer. Odd-even mass differences in self-consistent Mean-Field calculations. 2007. ⟨in2p3-00193952⟩
  • J. Tabet, S. Eden, S. Feil, H. Abdoul-Carime, B. Farizon, et al.. Ionization of biomolecules by proton impact: separation of direct ionization and electron capture processes and measurement of absolute cross sections. CECAM workshop "Modelling Radiation Damage", Dec 2007, Lyon, France. ⟨in2p3-00401803⟩
  • M. Farizon. Présentation D'ANAFIRE Plateau Technologique de l'IPN de Lyon “ Analyse et Faisceaux d'Ions pour La Radiobiologie et l'Environnement. Conseil Scientifique de l'Université Claude Bernard Lyon 1, Dec 2007, Lyon, France. ⟨in2p3-00401863⟩
  • R. Barbier. Expected Feedback from 3D IT for Imaging. LHC-ILC Workshop on 3D Integration Technique, Nov 2007, Palaiseau, France. ⟨in2p3-00407673⟩
  • D. Davesne. Regularization Cut-off Method with Symmetry Conservation. Electroweak Interactions with Nuclei and Physics of the QGP : Many-body Techniques at High Energies and Temperatures, Nov 2007, Trento, Italy. ⟨in2p3-00406388⟩

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