Health (PRISME)
- Presentation
- Activities
- Members
- Publications
The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.
Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.
One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.
The activities can be divided into three research areas:
Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.
Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.
Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.
NON-PERMANENTS:
- DOCTORANTS / DOCTORAL STUDENTS:
- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for pair production of doubly-charged Higgs bosons in the
final state. Physical Review Letters, 2008, 101, pp.071803. ⟨10.1103/PhysRevLett.101.071803⟩. ⟨in2p3-00263421⟩ - V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. ZZ to llvv production in pp collisions at sqrt(s) = 1.96 TeV. Physical Review D, 2008, 78, pp.072002. ⟨10.1103/PhysRevD.78.072002⟩. ⟨in2p3-00309003⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for Large Extra Dimensions via Single Photon plus Missing Energy Final States at sqrt(s) = 1.96 TeV. Physical Review Letters, 2008, 101, pp.011601. ⟨10.1103/PhysRevLett.101.011601⟩. ⟨in2p3-00264377⟩
- V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for anomalous
couplings in single top quark production. Physical Review Letters, 2008, 101, pp.221801. ⟨10.1103/PhysRevLett.101.221801⟩. ⟨in2p3-00295010⟩ - V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Erratum: measurement of
(
. Br (
at 
= 1.96- TeV [Phys. Rev. D 71, 072004 (2005)]. Physical Review D, 2008, 77, pp.039901(E). ⟨10.1103/PhysRevD.77.039901⟩. ⟨in2p3-00215940⟩ - V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for squarks and gluinos in events with jets and missing transverse energy using 2.1 fb-1 of ppbar collision data at sqrt(s)=1.96 TeV. Physics Letters B, 2008, 660, pp.449-457. ⟨10.1016/j.physletb.2008.01.042⟩. ⟨in2p3-00201676⟩
- A. Deandrea, A. Nehme, P. Talavera. Determination of light quark masses from eta-->3pi0. Physical Review D, 2008, 78, pp.034032. ⟨10.1103/PhysRevD.78.034032⟩. ⟨in2p3-00271540⟩
- J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Higgs boson searches in CP-conserving and CP-violating MSSM scenarios with the DELPHI detector. European Physical Journal C: Particles and Fields, 2008, 54, pp.1-35. ⟨10.1140/epjc/s10052-007-0506-1⟩. ⟨in2p3-00215947⟩
- J. Abdallah, P. Abreu, W. Adam, P. Adzic, T. Albrecht, et al.. Di-jet production in γ γ collisions at LEP2. European Physical Journal C: Particles and Fields, 2008, 58, pp.531-541. ⟨10.1140/epjc/s10052-008-0777-1⟩. ⟨in2p3-00348288⟩
- J. Bartel, K. Bencheikh, J. Meyer. Extended Thomas-Fermi density functionals in the presence of a tensor interaction in spherical symmetry. Physical Review C, 2008, 77, pp.024311. ⟨10.1103/PhysRevC.77.024311⟩. ⟨in2p3-00260258⟩
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