Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

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- DOCTORANTS / DOCTORAL STUDENTS:
    8790 documents

    • Rainer Stiele, Wanda Maria Alberico, Andrea Beraudo, Renan Câmara Pereira, Pedro Costa, et al.. Aspects of isentropic trajectories in chiral effective models. 6th FAIR next generation scientists workshop 2019, May 2019, Genova, Italy. pp.012043, ⟨10.1088/1742-6596/1667/1/012043⟩. ⟨hal-02317310⟩
    • Nicolas Baillot d'Étivaux, JĂ©rĂ´me Margueron, Sebastien Guillot, Natalie Webb, MĂ rcio Catelan, et al.. Constraining the equation of state of dense nuclear matter using thermal emission of neutron stars. 6th FAIR next generation scientists workshop 2019, May 2019, Genova, Italy. pp.012001, ⟨10.1088/1742-6596/1667/1/012001⟩. ⟨hal-03047523⟩
    • Pierros Ntelis, Adam James Hawken, Stephanie Escoffier, Anne Ealet, Andre Tilquin. Cosmological constraints from cosmic homogeneity. 2019. ⟨hal-02129901⟩
    • Alina Goldkuhle, Christoph Fransen, Alfred Dewald, Navin Alahari, Marcel Beckers, et al.. Preliminary results of lifetime measurements in neutron-rich ^{53}Ti. 4th International Conference on Nuclear Structure and Dynamics, May 2019, Venice, Italy. pp.01022, ⟨10.1051/epjconf/201922301022⟩. ⟨hal-02409992⟩
    • N. Chanon, A. Carle, S. Perries. Prospects for Lorentz-Violation Searches at the LHC and Future Colliders. 8th Meeting on CPT and Lorentz Symmetry, May 2019, Bloomington, United States. pp.45-48, ⟨10.1142/9789811213984_0012⟩. ⟨hal-02309014⟩
    • A. Carle, N. Chanon, S. Perriès. Prospects for Lorentz-Violation Searches with Top Pair Production at the LHC and Future Colliders. 8th Meeting on CPT and Lorentz Symmetry, May 2019, Bloomington, United States. pp.204-206, ⟨10.1142/9789811213984_0052⟩. ⟨hal-02302835⟩
    • Jules Gascon. Above-ground direct searches for WIMPs. An Alpine LHC Physics Summit 2019, Apr 2019, Obergurgl, Austria. pp.029, ⟨10.22323/1.360.0029⟩. ⟨hal-03150542⟩
    • T. Salbaing, L. Feketeová, Florent Calvo, B. Farizon, M. Farizon, et al.. Elimination of a water molecule by a protonated methanol cluster. 13th European Conference on Atoms Molecules and Photons (ECAMP 2019), Apr 2019, Florence, Italy. ⟨in2p3-02099643⟩
    • R. Meissner, C. Lochmann, L. Feketeová, J. Kocisek, J. Fedor, et al.. Low-energy electron interaction with nitroimidazole-based radiosensitisers under isolated and hydrated conditions. 13th European Conference on Atoms Molecules and Photons (ECAMP 2019), Apr 2019, Florence, Italy. ⟨in2p3-02099623⟩
    • T. Salbaing, L. Feketeová, Florent Calvo, B. Farizon, M. Farizon, et al.. Dissociation of a molecule evaporated from an excited protonated methanol nanodroplet. 13th European Conference on Atoms Molecules and Photons (ECAMP 2019), Apr 2019, Florence, Italy. ⟨in2p3-02099659⟩

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