Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Observation of the B_c Meson in the Exclusive Decay B_c \to J/\psi \pi. Physical Review Letters, 2008, 101, pp.012001. ⟨10.1103/PhysRevLett.101.012001⟩. ⟨in2p3-00259690⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Simultaneous measurement of the ratio B(t->Wb)/B(t->Wq) and the top quark pair production cross section with the D0 detector at sqrt(s)=1.96 TeV. Physical Review Letters, 2008, 100, pp.192003. ⟨10.1103/PhysRevLett.100.192003⟩. ⟨in2p3-00203403⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. First study of the radiation-amplitude zero in Wgamma production and limits on anomalous WWgamma couplings at sqrt(s)=1.96 TeV. Physical Review Letters, 2008, 100, pp.241805. ⟨10.1103/PhysRevLett.100.241805⟩. ⟨in2p3-00260989⟩
  • N. Bree, I. Stefanescu, P.A. Butler, J. Cederkäll, T. Davinson, et al.. Coulomb excitation of ^{68}Ni at safe energies. Physical Review C, 2008, 78, pp.047301. ⟨10.1103/PhysRevC.78.047301⟩. ⟨in2p3-00266844⟩
  • X. Artru, R. Chehab, M. Chevallier, V.M. Strakhovenko, A. Variola, et al.. Polarized and unpolarized positron sources for electron-positron colliders. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2008, 266, pp.3868-3875. ⟨10.1016/j.nimb.2008.02.086⟩. ⟨in2p3-00264841⟩
  • A. Anokhina, S. Aoki, A. Ariga, L. Arrabito, D. Autiero, et al.. Study of the effects induced by lead on the emulsion films of the OPERA experiment. Journal of Instrumentation, 2008, 3, pp.P07002. ⟨10.1088/1748-0221/3/07/P07002⟩. ⟨in2p3-00312837⟩
  • Muhammad Khokhar, Frédéric Grondin, Philippe Turcry, Ahmed Loukili, Pierre Mounanga. Comportement mécanique et déformations libres de mortiers à forts dosages en addition minérales. GEODIM08, 2008, Saint-Nazaire, France. ⟨hal-01008003⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for scalar neutrino superpartners in e + \mu final states in p\bar p collisions at \sqrt{s} =1.96 TeV. Physical Review Letters, 2008, 100, pp.241803. ⟨10.1103/PhysRevLett.100.241803⟩. ⟨in2p3-00189535⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the electron charge asymmetry in ppbar->W+X->enu+X events at sqrt{s}=1.96 TeV. Physical Review Letters, 2008, 101, pp.211801. ⟨10.1103/PhysRevLett.101.211801⟩. ⟨in2p3-00304363⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of differential Z/gamma*+jet+X cross sections in proton anti-proton collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2008, 669, pp.278-286. ⟨10.1016/j.physletb.2008.09.060⟩. ⟨in2p3-00310962⟩

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