Health (PRISME)

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The PRISME team is composed of physicists, biochemists, biologists and radiotherapists. We specialize in multidisciplinary research aimed at developing, optimizing and controlling innovative radiotherapies, whether it be hadrontherapy or therapies using radioactive ion-emitting elements or nanoparticles. These radiotherapies aim to improve the treatment of certain cancers by increasing the effect of ionizing radiation in the tumor while minimizing its harmful effects on healthy tissues.

Our multidisciplinary approach aims to quantify, understand and predict the effect of ionizing radiation on living organisms from processes induced at extremely short times (attosecond) at small scales (atomic nucleus) to long-term consequences (years) at the patient level.
We therefore design and carry out irradiation experiments on targets ranging from molecules or cells to small animals and patient samples (tumor, blood). These experiments feed an important part of our activity which consists in modeling the effects of radiation on living organisms.

One of the innovative techniques of radiotherapy is hadrontherapy, which is to send
an ion beam on the tumors to destroy them. We are working, in particular using simulations, data processing and predictions, to improve these systems by having on-line control over irradiation using dedicated detectors. These tools also have applications in imaging.

The activities can be divided into three research areas:

Axis 1 aims to develop simulations and detectors to control patient irradiation by detecting the particles emitted during hadrontherapy treatment. These developments also offer application prospects in the field of diagnostic imaging.

Axis 2 focuses on the development of multi-scale models and simulations to describe and predict the physical, chemical and biological processes induced by irradiation. It also develops irradiation and dosimetric control means for the measurement of radiobiological effects.

Axis 3 quantifies by experiment the effects induced by irradiation with molecular, cellular, multicellular, in-vitro or in-vivo systems. It focuses on the specificities of innovative radiotherapies and the personalization of care.

PERMANENTS:

NON-PERMANENTS:

- DOCTORANTS / DOCTORAL STUDENTS:

- CHERCHEURS NON-PERMANENTS / NON-PERMANENT RESEARCHERS:
8786 documents

  • Muhammad Khokhar, Frédéric Grondin, Philippe Turcry, Ahmed Loukili, Pierre Mounanga. Comportement mécanique et déformations libres de mortiers à forts dosages en addition minérales. GEODIM08, 2008, Saint-Nazaire, France. ⟨hal-01008003⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the shape of the boson transverse momentum distribution in p\bar{p} \to Z/\gamma* \to e^+e^- +X events produced at \sqrt{s}=1.96 TeV. Physical Review Letters, 2008, 100, pp.102002. ⟨10.1103/PhysRevLett.100.102002⟩. ⟨in2p3-00194219⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Search for scalar neutrino superpartners in e + \mu final states in p\bar p collisions at \sqrt{s} =1.96 TeV. Physical Review Letters, 2008, 100, pp.241803. ⟨10.1103/PhysRevLett.100.241803⟩. ⟨in2p3-00189535⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Evidence for production of single top quarks. Physical Review D, 2008, 78, pp.012005. ⟨10.1103/PhysRevD.78.012005⟩. ⟨in2p3-00260985⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the forward-backward charge asymmetry and extraction of sin^2Theta^{eff}_W in p\bar{p} \to Z/\gamma^{*}+X \to e^+e^-+X events produced at \sqrt{s}=1.96 TeV. Physical Review Letters, 2008, 101, pp.191801. ⟨10.1103/PhysRevLett.101.191801⟩. ⟨in2p3-00274974⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of differential Z/gamma*+jet+X cross sections in proton anti-proton collisions at sqrt{s}=1.96 TeV. Physics Letters B, 2008, 669, pp.278-286. ⟨10.1016/j.physletb.2008.09.060⟩. ⟨in2p3-00310962⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the muon charge asymmetry from W boson decays. Physical Review D, 2008, 77, pp.011106. ⟨10.1103/PhysRevD.77.011106⟩. ⟨in2p3-00178308⟩
  • V.M. Abazov, B. Abbott, M. Abolins, B.S. Acharya, M. Adams, et al.. Measurement of the electron charge asymmetry in ppbar->W+X->enu+X events at sqrt{s}=1.96 TeV. Physical Review Letters, 2008, 101, pp.211801. ⟨10.1103/PhysRevLett.101.211801⟩. ⟨in2p3-00304363⟩
  • L. Manduci, O. Lopez, J.C. Steckmeyer, B. Borderie, R. Bougault, et al.. Multifragmentation threshold in ^{93}Nb+{nat}Mg collisions at 30 MeV/nucleon. Nuclear Physics A, 2008, 811, pp.93-106. ⟨10.1016/j.nuclphysa.2008.07.007⟩. ⟨hal-00277843⟩
  • O. Lopez-Pamies, R. Garcia, E. Chabert, J.-Y. Cavaillé, P. Ponte Castañeda. Multiscale modeling of oriented thermoplastic elastomers with lamellar morphology. Journal of the Mechanics and Physics of Solids, 2008, 56 (11), pp.3206-3223. ⟨10.1016/j.jmps.2008.07.008⟩. ⟨hal-01815415⟩

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